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Adolescents and adults with Fontan circulation: insights from the PREpArE-Fontan registry.

Author: AboulhosnJamil, CliftPaul, FaureCéline, FranklinWayne J, HagerAlfred, KimYuli Y, Muros-Le RouzicErwan, RosenbergDaniel, SchwerzmannMarkus, SøndergaardLars, d'UdekemYves

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes a cohort of patients with stable Fontan circulation who could potentially participate in a clinical trial investigating macitentan, an endothelin receptor antagonist. The study found that 53.4% of patients met the eligibility criteria and identified early signs of Fontan failure, even in stable patients.
Paper Details　
Original Abstract of the Article :
The Patient Registry for Adolescents and Adults with Stable Fontan Circulation aims to describe a contemporary cohort of Fontan patients who could be eligible for a clinical trial investigating macitentan, an endothelin receptor antagonist. This international, non-interventional, multicentre, cross-...See full text at original site
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引用元：
https://doi.org/10.1017/S1047951121002791

データ提供：米国国立医学図書館（NLM）

Fontan Circulation: A Look at Adolescents and Adults

Fontan circulation is a surgical procedure used to address complex heart defects in children. This study examines the characteristics and outcomes of a contemporary cohort of adolescents and adults with Fontan circulation, using data from the PREpArE-Fontan registry. The researchers aim to describe this population, highlighting key characteristics and potential areas for further research.

Fontan Circulation: A Complex and Challenging Condition

The study reveals that patients with Fontan circulation often face challenges, including arrhythmias and potential for heart failure. The researchers found that the majority of patients were in NYHA functional class I or II, indicating a relatively good functional status. However, they also observed a higher prevalence of arrhythmias and lower creatinine clearance, suggesting potential for future complications.

Improving Outcomes for Individuals with Fontan Circulation

This research highlights the importance of long-term monitoring and management for patients with Fontan circulation. The study's findings underscore the need for continued research to understand the long-term outcomes and develop effective interventions for managing potential complications.

Dr.Camel's Conclusion

Living with Fontan circulation can be like navigating a desert with shifting landscapes. This study provides valuable insights into the characteristics and challenges faced by adolescents and adults with this condition. Continued research and careful monitoring are essential to ensure a successful journey through this complex terrain.

Date :
  1. Date Completed 2022-05-09
  2. Date Revised 2022-05-09
Further Info :

Pubmed ID

34294186

DOI: Digital Object Identifier

10.1017/S1047951121002791

Related Literature

Article Analysis
・Effects of macitentan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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