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Design, synthesis and biological evaluation of novel 5-(imidazolyl-methyl) thiazolidinediones as antidiabetic agents.

Author: GhodsiRazieh, HadizadehFarzin, KarimiGholamreza, MosaffaFatemeh, PasebanMaryam, SahebkarAmirhossein, ShakourNeda, TasbandiAida, Tayarani-NajaranZahra

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new series of imidazolyl-methyl-l-2,4-thiazolidinediones showed anti-hyperglycemic activity in a diabetic-control group, without toxicity in 3T3 cells. Compounds 9e and 9b were more effective than pioglitazone at lowering blood glucose and showed similar PPAR-γ gene expression behavior.
Paper Details　
Original Abstract of the Article :
A newly designed series of imidazolyl-methyl- l-2,4-thiazolidinediones 9 (a-m) were synthesized and In Silico studies were carried out to rationalize their anti-diabetic activity. Generally, all newly synthesized thiazolidinediones had anti-hyperglycemic activity compared with a diabetic-control gro...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2021.105162

データ提供：米国国立医学図書館（NLM）

A Novel Approach to Antidiabetic Treatment: Seeking a New Oasis in the Desert of Diabetes

This study explores the potential of a new class of compounds, 5-(imidazolyl-methyl)thiazolidinediones, as antidiabetic agents. It's like searching for a hidden oasis in a desert, seeking a new and effective treatment for this challenging condition. The researchers synthesized and tested these compounds in laboratory models, demonstrating their effectiveness in lowering blood glucose levels and improving glucose uptake in cells. The study suggests that these compounds hold promise as a new therapeutic approach for diabetes, offering potential benefits over existing treatments.

A Promising New Direction in Diabetes Treatment

This study reveals the potential of a new class of compounds as antidiabetic agents. It's like discovering a new route through a desert, offering a more efficient and effective path. The findings suggest that these compounds may offer a safer and more effective alternative to existing treatments, potentially improving the lives of millions affected by diabetes.

Hope for a Healthier Future: A Desert Oasis of Treatment Options

Diabetes is a growing global health concern, impacting millions worldwide. It's like a desert spreading across the landscape, threatening the well-being of countless individuals. This study provides hope for a healthier future, suggesting a new and promising avenue for diabetes treatment.

Dr.Camel's Conclusion

This study offers hope for a healthier future for individuals with diabetes, revealing the potential of a new class of compounds as antidiabetic agents. It’s like discovering a new oasis in a vast and unforgiving desert, providing a refreshing source of hope and potential relief. The findings highlight the importance of continued research and innovation in the field of diabetes treatment, seeking new solutions to address this growing global health challenge.

Date :
  1. Date Completed 2021-12-13
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

34314919

DOI: Digital Object Identifier

10.1016/j.bioorg.2021.105162

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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