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Effects of topiramate on the association between affect, cannabis craving, and cannabis use in the daily life of youth during a randomized clinical trial.

Author: CarpenterRyan W, EmeryNoah N, MeiselSamuel N, MirandaRobert

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Topiramate, an anticonvulsant, is being studied for substance use disorders. It is thought to reduce substance use by attenuating craving and reward effects. This paper explores whether topiramate attenuates the association of affect and craving with substance use.
Paper Details　
Original Abstract of the Article :
Topiramate is an anticonvulsant currently under study for treating substance use disorders. Topiramate is thought to reduce substance use by attenuating craving and the rewarding effects of acute substance use through its concurrent GABAergic agonism and glutamatergic antagonism. Importantly, topira...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34331080

データ提供：米国国立医学図書館（NLM）

Topiramate's Impact on Affect, Craving, and Cannabis Use in Youth

Topiramate, an anticonvulsant medication, is being investigated as a potential treatment for substance use disorders, including cannabis use. This study investigates the impact of topiramate on the relationship between affect, cannabis craving, and cannabis use in youth. The study design involved a randomized clinical trial, a rigorous approach to evaluating the effects of a treatment.

The researchers aimed to determine whether topiramate could attenuate the associations between mood states, craving, and cannabis use. They found that topiramate had an impact on mood states, which are central to many models of substance use. However, the study did not find conclusive evidence that topiramate directly attenuated the association between affect and craving with cannabis use.

Topiramate: A Complex Impact on Substance Use

This research suggests that topiramate may influence mood states, which are significant in substance use. However, further research is needed to better understand the complex interactions between topiramate, affect, craving, and cannabis use.

Substance Use Treatment: A Holistic Approach

Treating substance use disorders is a multifaceted process. It often involves a combination of medications, therapy, and support systems. This study underscores the importance of further research to understand the nuanced effects of medications like topiramate on various aspects of substance use.

Dr. Camel's Conclusion

Imagine a young camel struggling to navigate the shifting sands of addiction. Topiramate, in this metaphor, is a guide who may help to steady the camel's path, but the journey remains challenging. This study highlights the complexities of treating substance use disorders and emphasizes the need for more research to fully understand the potential benefits and risks of various treatments.

Date :
  1. Date Completed 2021-11-23
  2. Date Revised 2022-08-11
Further Info :

Pubmed ID

34331080

DOI: Digital Object Identifier

NIHMS1784707

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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