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Mechanisms and Potential Treatment Options of Heart Failure in Patients With Multiple Myeloma.

Author: JadaKeji, Kakieu DjossiSandrine, KhedrAnwar, MostafaJihan A, NeupaneBandana, ProskuriakovaEkaterina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Multiple myeloma, a cancer of plasma cells, often leads to heart failure as a side effect of treatment. Cardiac amyloidosis can also cause heart failure. This article discusses the molecular mechanisms of heart failure in multiple myeloma patients, including doxorubicin cardiotoxicity and proteasome inhibitors' effects. Potential treatment options, such as liposomal doxorubicin, mitochondrial biogenesis enhancers, and cardioprotective agents, are explored.
Paper Details　
Original Abstract of the Article :
Multiple myeloma is a pathology of plasma cells, with one of the most common side effects of its treatment is heart failure. In addition, cardiac amyloidosis could cause heart failure by itself. Even though mechanisms of cardiac amyloidosis are known, and they involve lysosomal dysfunction, reactive...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312996/

データ提供：米国国立医学図書館（NLM）

Heart Failure in Multiple Myeloma: Understanding the Complexities

Multiple myeloma, a type of blood cancer, can be like a sandstorm, disrupting the delicate balance of the body's systems. This study explores the complex relationship between multiple myeloma and heart failure, a condition that weakens the heart's ability to pump blood effectively.

Unraveling the Mechanisms of Heart Failure in Multiple Myeloma

The authors delve into the various mechanisms that can lead to heart failure in patients with multiple myeloma, including treatment-related cardiotoxicity and the development of cardiac amyloidosis. It's like piecing together a desert puzzle, understanding the various factors that contribute to this challenging condition.

Exploring Potential Treatment Options

The study highlights the need for research into new treatments to protect against heart failure in multiple myeloma patients. It's like seeking out a hidden oasis in the desert, searching for new solutions to address this complex problem. The authors discuss the potential of agents like dexrazoxane, liposomal doxorubicin, and metformin, offering hope for improved patient outcomes.

Dr.Camel's Conclusion

This study sheds light on the complex relationship between multiple myeloma and heart failure, offering a comprehensive overview of the underlying mechanisms and potential treatment options. The research underscores the importance of continued exploration and innovation in this field to improve the lives of patients living with multiple myeloma.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-07
Further Info :

Pubmed ID

34336442

DOI: Digital Object Identifier

PMC8312996

SNS
PICO Info
in preparation
Languages

English

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