DARK Classics in Chemical Neuroscience: Loperamide.

Author: HanChangho, LindsleyCraig W, MalinkyCori A

Paper Details 
Original Abstract of the Article :
Loperamide, a popular and inexpensive over-the-counter antidiarrheal medicine, is a potent μ-opioid receptor agonist approved by the U.S. Food and Drug Administration (FDA). It has been on the market since 1976 and is relatively safe with no central nervous system-related side effects when used for ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1021/acschemneuro.1c00382

データ提供:米国国立医学図書館(NLM)

Loperamide: A Common Antidiarrheal, But With Potential for Abuse

Loperamide, a widely available over-the-counter antidiarrheal medication, has proven to be a valuable tool in managing gastrointestinal distress. However, like a desert oasis that can be misused, loperamide has also become a target of abuse, particularly by individuals with substance dependence. This review delves into the chemical properties, pharmacology, and adverse effects of loperamide, exploring the reasons behind its abuse and the efforts made to mitigate it. The authors examine the complex interplay between loperamide's therapeutic benefits and its potential for misuse, offering a nuanced perspective on this common medication.

Loperamide's Complex Landscape: Balancing Benefits and Risks

This review, like a desert traveler navigating a treacherous landscape, explores the complex nature of loperamide, a medication with both therapeutic benefits and potential for abuse. The authors highlight the increased risk of loperamide overdose due to self-administered medication to treat opioid withdrawal symptoms, underscoring the importance of careful monitoring and responsible use of this medication. This approach emphasizes the need for a balanced perspective, recognizing both the benefits and risks associated with loperamide.

Navigating the Desert of Substance Abuse: Informed Choices and Responsible Use

Substance abuse, like a shifting sandstorm in the desert, can have devastating consequences. This review underscores the importance of understanding the potential for abuse, even with seemingly harmless medications like loperamide. It emphasizes the need for informed choices and responsible use, promoting a balanced and healthy approach to managing both physical and mental well-being.

Dr.Camel's Conclusion

This review, like a seasoned desert guide offering a word of caution, explores the complex landscape of loperamide, a medication with both therapeutic benefits and potential for misuse. Remember, like navigating a desert, responsible use and a balanced perspective are crucial for minimizing risks and maximizing well-being.

Date :
  1. Date Completed 2021-09-03
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

34346690

DOI: Digital Object Identifier

10.1021/acschemneuro.1c00382

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.