Hydralazine and Panobinostat Attenuate Malignant Properties of Prostate Cancer Cell Lines.

Author: CamiloVânia, CorreiaMargareta P, HenriqueRui, JerónimoCarmen, LopesNair, Moreira-SilvaFilipa, PachecoMariana Brütt

Paper Details 
Original Abstract of the Article :
Among the well-established alterations contributing to prostate cancer (PCa) pathogenesis, epigenetics is an important player in its development and aggressive disease state. Moreover, since no curative therapies are available for advanced stage disease, there is an urgent need for novel therapeutic...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308508/

データ提供:米国国立医学図書館(NLM)

A New Weapon in the Desert: Hydralazine and Panobinostat for Prostate Cancer

Prostate cancer (PCa) is a significant health challenge, with advanced stages proving particularly difficult to treat. This research investigates the combined antineoplastic effects of hydralazine, a DNA methylation inhibitor, and panobinostat, a histone deacetylase inhibitor, in several prostate cell lines. The study aimed to evaluate the potential of these drugs as a novel therapeutic strategy for aggressive PCa.

A Desert Oasis of Hope: Combating Prostate Cancer

The study found that combining hydralazine and panobinostat led to synergistic growth inhibitory effects in PCa cells, impacting cell viability, proliferation, and invasion. These findings suggest that this combination therapy could offer a promising approach for treating aggressive PCa.

Navigating the Sands of Prostate Cancer Treatment

Imagine a desert traveler facing a formidable sand dune, a metaphor for the challenges of treating advanced prostate cancer. This research presents a novel approach, like a hidden oasis, offering a potential weapon to combat this challenging disease.

Dr.Camel's Conclusion

This research sheds light on the potential of combining hydralazine and panobinostat as a novel therapeutic strategy for aggressive prostate cancer. The synergistic effects of these drugs demonstrate their promise as a potent tool for combating this challenging disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-08-09
Further Info :

Pubmed ID

34358096

DOI: Digital Object Identifier

PMC8308508

Related Literature

SNS
PICO Info
in preparation
Languages

English

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