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Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID-19 Patients.

Author: García-TrejoJosé J, OrtegaRaquel, Zarco-ZavalaMariel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Lamivudine, also known as 3TC, is a drug used to treat HIV-1 and chronic Hepatitis B infections. It can also be used to prevent HBV reactivation during chemotherapy and has shown potential for use against SARS-CoV-2. Lamivudine has established anti-cancer properties and is being investigated as an anti-COVID agent. Side effects and resistance to 3TC are discussed.
Paper Details　
Original Abstract of the Article :
Lamivudine, also widely known as 3TC belongs to a family of nucleotide/nucleoside analogues of cytidine or cytosine that inhibits the Reverse Transcriptase (RT) of retroviruses such as HIV. Lamivudine is currently indicated in combination with other antiretroviral agents for the treatment of HIV-1 i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335563/

データ提供：米国国立医学図書館（NLM）

Repurposing Lamivudine: A Versatile Drug with New Potential

This study explores the potential for [lamivudine (3TC)] to be repurposed for the treatment of [cancer] and [COVID-19]. Lamivudine is a well-established [antiretroviral drug] that inhibits the [reverse transcriptase] of retroviruses like HIV. This study reviews recent research suggesting that lamivudine might also have therapeutic potential against SARS-CoV-2 and could potentially improve the outcomes of cancer patients. Imagine finding a versatile tool in the desert that can be used for multiple purposes - a sturdy camel can carry heavy loads, but it can also be used for plowing fields or transporting people.

Lamivudine: A Promising Drug with Multiple Applications

The study highlights the potential of lamivudine to be repurposed for treating both cancer and COVID-19. The authors present evidence suggesting that lamivudine might have antiviral activity against SARS-CoV-2 and could potentially enhance the effectiveness of chemotherapy. This is like discovering a new type of plant in the desert that can be used for both food and medicine. It's a versatile resource with multiple benefits.

Understanding the Potential of Lamivudine

This study encourages further research into the potential of lamivudine for treating cancer and COVID-19. The authors acknowledge that the evidence is still emerging, but they encourage additional clinical trials to investigate the drug's potential benefits. It's like exploring a newly discovered oasis - we need to investigate its resources and potential before we can fully understand its value.

Dr. Camel's Conclusion

This study offers a fascinating glimpse into the potential of repurposing existing drugs for new applications. Lamivudine's versatility and safety profile make it a promising candidate for treating cancer and COVID-19, but further research is needed to fully understand its potential benefits. This research is like finding a new path through the desert - it offers hope for a brighter future for patients battling cancer and COVID-19.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-08-10
Further Info :

Pubmed ID

34367956

DOI: Digital Object Identifier

PMC8335563

Related Literature

Article Analysis
・Side Effects of 3tc
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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