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Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats.
Author: BolanowskiMarek, DomrazekKinga, DziewiszekWojciech, EberhardtMaria, HeinrichAgata, JawieńPaulina, JędrzejukDiana, JęśkowiakIzabela, KwiatkowskaJoanna, MatuszewskaAgnieszka, Merwid-LądAnna, NikodemAnna, NiżańskiWojciech, NowakBeata, OlejnikKamil, PiotrowskaAleksandra, Podhorska-OkołówMarzenna, RutkowskaMaria, SozańskiTomasz, SzelągAdam, SzelągEwa, TomkalskiTomasz, WiatrakBenita, ZduniakKrzysztof
Original Abstract of the Article :
Highly active antiretroviral therapy (HAART) is used in HIV-infected patients. Alongside the prolongation of patients' life, adverse side effects associated with long-term therapy are becoming an increasing problem. Therefore, optimizing of HAART is extremely important. The study is aimed at evaluat...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349296/
データ提供：米国国立医学図書館（NLM）
Navigating the Desert of Antiretroviral Therapy Side Effects
The field of HIV treatment has made significant strides, but long-term therapy often comes with a desert of potential side effects. This study investigates the impact of long-term administration of abacavir and etravirine, two antiretroviral drugs, on various physiological systems in growing male rats. The researchers, like scientists seeking to understand the complex interplay between medications and the body, analyzed the effects of these drugs on reproductive health, liver function, kidney function, and bone metabolism. This study provides valuable insights into the long-term consequences of antiretroviral therapy, highlighting the importance of ongoing research to mitigate potential adverse effects.
Long-Term Effects of Abacavir and Etravirine on Semen Quality and Bone Metabolism
The study revealed that long-term administration of abacavir and etravirine had significant effects on semen quality and bone metabolism in rats. The findings suggest that these drugs could potentially impact fertility and bone health in humans, emphasizing the importance of monitoring these systems in patients receiving long-term antiretroviral therapy.
Implications for HIV Treatment and Future Research
The study underscores the importance of considering the long-term implications of antiretroviral therapy on various physiological systems. Future research should focus on developing strategies to mitigate the potential side effects of these medications, potentially leading to safer and more effective treatment options for HIV patients.
Dr.Camel's Conclusion
This research highlights the importance of comprehensive monitoring in patients receiving long-term antiretroviral therapy. The study's findings emphasize the need for ongoing research to understand the long-term consequences of these medications, ensuring a safer and more informed approach to treating HIV.
Date :
- Date Completed 2022-01-06
- Date Revised 2022-01-06
Further Info :
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