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Profiling the physiological pitfalls of anti-hepatitis C direct-acting agents in budding yeast.

Author: Abdel-DaimMohamed M, AbdelmoatyAhmed A, AlmeerRafa, Hashem MohamedNashwa, HessSteffen, JuraibyIbrahim, MetwallyKamel, MosbahRasha, PijuanJordi, SeleemNoura M, Shulaywih AlshamanHamoud, StorchovaZuzana, YahyaGalal

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sofosbuvir and Daclatasvir, direct-acting antiviral medications, are effective for treating chronic hepatitis C. Although they have high cure rates and are well-tolerated, concerns about adverse cardiac side effects, recurrence, and genotoxicity have been raised. This study found that these drugs disturb the architecture of the endoplasmic reticulum (ER) and mitochondria but do not cause genotoxicity. Antioxidant therapy is recommended to mitigate the negative effects on ER and mitochondria.
Paper Details　
Original Abstract of the Article :
Sofosbuvir and Daclatasvir are among the direct-acting antiviral (DAA) medications prescribed for the treatment of chronic hepatitis C (CHC) virus infection as combination therapy with other antiviral medications. DAA-based therapy achieves high cure rates, reaching up to 97% depending on the genoty...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8449668/

データ提供：米国国立医学図書館（NLM）

Exploring the Physiological Effects of Anti-Hepatitis C Direct-Acting Agents: A Journey Through the Cellular Desert

Hepatitis C is a serious viral infection that can have devastating consequences for the liver. This study examines the physiological effects of direct-acting antiviral agents (DAAs), like sofosbuvir and daclatasvir, used to treat chronic hepatitis C. The researchers used budding yeast, a unicellular organism, as a model to study the impact of these drugs on cellular organelles.

Navigating the Cellular Desert: DAAs and Cellular Organelles

The study found that DAAs can disrupt the structure and function of key cellular organelles, like the endoplasmic reticulum and mitochondria. While DAAs were not found to be genotoxic, they can still have significant effects on cellular health. This underscores the importance of considering the broader impact of medications on the body, beyond their primary target.

Maintaining Cellular Harmony: A Journey Through the Desert of Treatment

Living with hepatitis C can be like navigating a vast and unforgiving desert. This study reminds us that even with effective treatments, like DAAs, it's important to be mindful of their potential side effects. The researchers suggest that antioxidant therapies may be beneficial in mitigating the negative effects of DAAs on cellular organelles, highlighting the need for a holistic approach to treatment.

Dr.Camel's Conclusion

This research provides valuable insights into the physiological effects of DAAs, highlighting the importance of considering their impact on cellular organelles beyond their direct antiviral activity. The study emphasizes the need for further research to optimize treatment regimens and minimize potential side effects, paving the way for a more effective and safe approach to managing hepatitis C.
Date :
  1. Date Completed 2021-10-05
  2. Date Revised 2021-10-05
Further Info :

Pubmed ID

34378349

DOI: Digital Object Identifier

PMC8449668

Related Literature

Article Analysis
・Side Effects of daclatasvir
SNS
PICO Info
in preparation
Languages

English

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