Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia.

Author: BergaminiGiorgio, ClozelMartine, RochCatherine, SteinerMichel A

Paper Details 
Original Abstract of the Article :
Dual orexin receptor antagonists (DORAs) represent a novel type of sleep medication that provide an alternative to the traditionally used positive allosteric gamma-aminobutyric acid (GABA)-A receptor modulators. Daridorexant is a new DORA that exhibited in phase 3 trials in insomnia not only a benef...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455402/

データ提供:米国国立医学図書館(NLM)

Daridorexant: A New Hope for Insomnia Sufferers

Insomnia, the unwelcome companion of sleepless nights, affects millions worldwide. This research explores the potential of a new drug, Daridorexant, as a treatment for insomnia. Imagine a camel struggling to find its way through a darkened desert, unable to find its usual resting place. This is the feeling of insomnia - a struggle to find peace and rest. This research presents Daridorexant as a potential guide, helping to illuminate the path to a more restful night's sleep.

Daridorexant, a dual orexin receptor antagonist (DORA), works by targeting the brain's natural sleep-wake cycle. The researchers highlight the unique features of Daridorexant, including its ability to promote natural sleep, preserve memory and cognition, and avoid the development of tolerance or physical dependence. Unlike traditional sleep aids, Daridorexant doesn't simply knock you out, but instead helps regulate your natural sleep patterns.

A New Dawn for Sleep: Daridorexant Offers a Gentle Approach to Insomnia

This study offers a promising new approach to treating insomnia, suggesting that Daridorexant could provide a safe and effective solution for those who struggle with sleep. It's a reminder that even in the challenging desert of sleeplessness, there are new paths to explore, leading to a more restful and rejuvenating night's sleep.

Dr. Camel's Conclusion

This research shines a light on the potential of Daridorexant to improve the lives of those suffering from insomnia. It's a reminder that the quest for better sleep continues, and there are always new horizons to explore in the vast desert of sleep research.

Date :
  1. Date Completed 2021-10-15
  2. Date Revised 2022-02-18
Further Info :

Pubmed ID

34415378

DOI: Digital Object Identifier

PMC8455402

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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