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Evaluation of Buprenorphine Rotation in Patients Receiving Long-term Opioids for Chronic Pain: A Systematic Review.

Author: GarpestadClaire, LagisettyPooja, PowellVictoria D, RosenbergJack M, ShannonCarol, SilveiraMaria J, YagantiAvani

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review synthesized the evidence on rotation to buprenorphine from long-term opioid therapy (LTOT) in individuals with chronic pain. The review found that buprenorphine was associated with reduced pain intensity without precipitating opioid withdrawal. Steady-dose buprenorphine was better tolerated than tapered-dose buprenorphine. Future research is needed to determine the optimal approach to buprenorphine rotation.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Individuals with chronic pain who use long-term opioid therapy (LTOT) are at risk of opioid use disorder and other harmful outcomes. Rotation to buprenorphine may be considered, but the outcomes of such rotation in this population have not been systematically reviewed. OBJECTIVE: To syn...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427372/

データ提供：米国国立医学図書館（NLM）

Buprenorphine Rotation: A Bridge Over Troubled Waters

Managing chronic pain can be a complex and challenging journey, often involving long-term opioid therapy (LTOT). This research explores the potential benefits and risks of rotating patients from full μ-opioid receptor agonists to buprenorphine, a medication used to treat opioid use disorder. The study aimed to synthesize evidence from various studies on buprenorphine rotation in patients with chronic pain receiving LTOT, assessing outcomes like precipitated withdrawal, pain intensity, treatment success, adverse events, and mental health.

The review of 22 studies suggested that buprenorphine rotation was associated with maintained or improved analgesia, with a low risk of precipitating opioid withdrawal. The studies also indicated that steady-dose buprenorphine was better tolerated than tapered-dose buprenorphine. However, the review highlighted the need for further research to determine optimal dosing and administration strategies for buprenorphine rotation.

Navigating the Waters of Opioid Management

This research provides valuable insights into the potential of buprenorphine rotation for managing chronic pain in patients receiving LTOT. The findings suggest that buprenorphine could offer a safer and more effective alternative to traditional opioids, potentially leading to improved pain control and reduced risk of opioid use disorder. However, further research is needed to optimize the use of buprenorphine for this purpose.

Building a Bridge to Recovery

The research on buprenorphine rotation for chronic pain management offers a potential bridge over troubled waters, connecting patients with a safer and potentially more effective treatment option. While further research is needed to refine the use of buprenorphine for this purpose, the findings suggest that it could offer a valuable tool for healthcare providers navigating the complexities of opioid management.

Dr. Camel's Conclusion

Buprenorphine rotation offers a potential bridge over troubled waters, connecting patients with chronic pain receiving LTOT to a safer and potentially more effective treatment option. While further research is needed, it's a promising approach that could lead to improved pain control and reduced risk of opioid use disorder.

Date :
  1. Date Completed 2022-01-10
  2. Date Revised 2022-04-23
Further Info :

Pubmed ID

34495339

DOI: Digital Object Identifier

PMC8427372

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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