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Effect of mifepristone and lithospermum combination regimen on medical abortion in early pregnancy rats.

Author: HuShifu, HuShihong, YuQiong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the optimal dose of mifepristone and lithospermum combination regimen on medical abortion in early pregnancy rats. The study found that 540 mg/kg lithospermum plus 1 mg/kg mifepristone significantly improved the abortion rate compared to the control group. The combination regimen did not induce a significant increase in factors associated with abnormal endometrial bleeding.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate the optimal dose of mifepristone and lithospermum combination regimen on medical abortion in early pregnancy rats without increasing side effects. STUDY DESIGN: Sixty sexually mature female Sprague Dawley (SD) rats with early pregnancy were randomly allocated into 10 group...See full text at original site
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引用元：
https://doi.org/10.1111/jog.15007

データ提供：米国国立医学図書館（NLM）

Investigating the Optimal Dosage of Mifepristone and Lithospermum for Medical Abortion

Medical abortion is a safe and effective option for terminating early pregnancies. This study aims to determine the optimal dose of a combination regimen of mifepristone and lithospermum for inducing medical abortion in rats, while minimizing potential side effects.

Identifying a Safe and Effective Dosage Regimen

The study reveals that a combination of 540 mg/kg lithospermum and 1 mg/kg mifepristone effectively induced abortion in rats, without significantly increasing factors associated with abnormal endometrial bleeding. This dosage regimen appears to be a promising option for medical abortion.

Understanding the Mechanisms of Medical Abortion

The study sheds light on the cellular mechanisms involved in medical abortion, showing that the combination regimen promotes apoptosis in the endometrium. This research provides valuable insights into the biological processes underlying medical abortion.

Dr.Camel's Conclusion

This research, like a skilled alchemist carefully balancing ingredients, investigates the optimal dose of mifepristone and lithospermum for medical abortion. The study provides valuable insights into a safe and effective treatment approach, offering hope for a more controlled and less invasive option for women seeking this medical procedure.

Date :
  1. Date Completed 2021-11-03
  2. Date Revised 2021-11-03
Further Info :

Pubmed ID

34505328

DOI: Digital Object Identifier

10.1111/jog.15007

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・Side Effects of mifepristone (korlym)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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