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Lung cancer treated abroad with receptor tyrosine kinase inhibitor.
Author: BrustugunOdd Terje, EideInger Johanne Zwicky
Original Abstract of the Article :
BACKGROUND: Activating RET fusions are oncogenic drivers in multiple cancers and are identified in 1-2 % of non-small cell lung cancers (NSCLC). Selpercatinib and pralsetinib are tyrosine kinase inhibitors selectively targeting RET and with clinical activity in RET-positive NSCLC. CASE PRESENTATION...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.4045/tidsskr.21.0147
データ提供:米国国立医学図書館(NLM)
Targeted Therapy for RET Fusion-Positive Lung Cancer
This case presentation delves into the exciting field of [precision medicine] by showcasing the successful treatment of [advanced lung adenocarcinoma] with a [tyrosine kinase inhibitor] targeting a specific genetic mutation. The patient presented with a [KIF5B-RET fusion], a rare genetic alteration that drives tumor growth. The use of [pralsetinib] through a [compassionate use program] resulted in [relief of symptoms] and [radiological partial response], demonstrating the effectiveness of targeted therapy in this context.
Precision Medicine: A Powerful Tool in the Fight Against Cancer
This case highlights the power of precision medicine in identifying and treating cancer based on individual genetic characteristics. The patient's response to pralsetinib, specifically targeting the KIF5B-RET fusion, showcases the potential of targeted therapies to deliver personalized and effective treatment.
The Shifting Sands of Cancer Treatment
The use of next-generation sequencing (NGS) to identify specific genetic mutations in cancer is a game-changer. It's like having a map to navigate the complex terrain of cancer treatment. By pinpointing the unique genetic drivers of each tumor, we can tailor treatment strategies for optimal outcomes. This approach represents a significant shift in the landscape of cancer care, offering hope and personalized solutions for patients.
Dr.Camel's Conclusion
This case study underscores the transformative power of precision medicine in cancer treatment. The identification and targeting of specific genetic alterations like KIF5B-RET fusion using NGS opens up new avenues for personalized therapy. It's akin to navigating the desert with a compass, leading us to a more effective and targeted path to conquer this formidable foe.
Date :
- Date Completed 2021-10-18
- Date Revised 2021-11-19
Further Info :
Related Literature
Norwegian
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