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Choosing the Most Efficacious and Safe Oral Treatment for Idiopathic Overactive Bladder: A Systematic Review and Network Meta-analysis.

Author: AydhAbdulmajeed, CarlinGreta Lisa, GrossmannNico C, HajebrahimiSakineh, JilchSandra, KatayamaSatoshi, KönigFrederik, LaukhtinaEkaterina, MoriKeiichiro, MostafaeiHadi, PradereBenjamin, QuhalFahad, RajwaPawel, RoehrbornClaus G, Salehi-PourmehrHanieh, Sari MotlaghReza, SchuettfortVictor M, ShariatShahrokh F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A network meta-analysis of 54 randomized controlled trials involving patients with idiopathic overactive bladder (IOAB) compared the efficacy of oral antimuscarinics and β-adrenoceptor agonists, considering adverse events. The most efficacious agents for reducing various overactive bladder symptoms varied depending on the specific symptom, and gastrointestinal problems were the most common adverse events. The findings highlight the importance of shared decision-making with patients to select the most appropriate treatment based on individual symptoms and tolerability.
Paper Details　
Original Abstract of the Article :
CONTEXT: The choice of the most efficacious drug for patients with idiopathic overactive bladder (IOAB) remains challenging. OBJECTIVE: The aim of this network meta-analysis was to determine the most efficacious oral antimuscarinic or β-adrenoceptor agonist accounting for adverse events for the man...See full text at original site
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引用元：
https://doi.org/10.1016/j.euf.2021.08.011

データ提供：米国国立医学図書館（NLM）

Overactive Bladder: Navigating a Sea of Treatment Options

Overactive bladder (OAB) is a common and often debilitating condition affecting millions worldwide. This network meta-analysis delves into the vast and complex landscape of oral treatments for idiopathic OAB, aiming to identify the most effective and safe options for patients. The authors meticulously analyzed a large dataset of randomized controlled trials, comparing the efficacy of different antimuscarinic and β-adrenoceptor agonist medications in reducing bothersome symptoms associated with OAB.

Finding the Right Anchor in a Stormy Sea: Personalized OAB Management

This comprehensive meta-analysis provides valuable insights into the relative efficacy of different oral medications for OAB. The study highlights the importance of individualized treatment approaches, considering the specific symptoms experienced by each patient and potential adverse events associated with different medications. It emphasizes the need for shared decision-making between patients and healthcare providers to ensure optimal outcomes and minimize side effects.

Understanding the Tides of OAB Management: A Personalized Approach

This research emphasizes the complexity of OAB management and the importance of a tailored approach. Finding the right medication for OAB is like navigating a stormy sea, where the right compass and navigation tools are essential for reaching the desired destination. This study offers a valuable roadmap for healthcare providers and patients, helping them to navigate the diverse options and find the most effective and safe treatment path.

Dr.Camel's Conclusion

Imagine a vast ocean with countless islands, each representing a different OAB treatment option. This study is like a compass that helps you navigate through this ocean of choices, finding the most effective and safe island to reach your desired destination—relief from OAB symptoms. The authors emphasize the importance of personalized treatment plans, reminding us that each journey is unique and requires careful consideration of the patient's individual needs and vulnerabilities. This research offers valuable insights for both healthcare providers and patients, helping them to navigate the challenging waters of OAB management and find the best possible treatment for their individual circumstances.

Date :
  1. Date Completed 2022-10-10
  2. Date Revised 2022-11-30
Further Info :

Pubmed ID

34563481

DOI: Digital Object Identifier

10.1016/j.euf.2021.08.011

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