Insights Into the Molecular Mechanisms of Polycystic Kidney Diseases.

Author: IlatovskayaDaria V, SudarikovaAnastasia V, SultanovaRegina F, VasilevaValeriia Y

Paper Details 
Original Abstract of the Article :
Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD) are severe multisystem genetic disorders characterized with formation and uncontrolled growth of fluid-filled cysts in the kidney, the spread of which eventually leads to the loss of renal function. Currently, ther...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456103/

データ提供:米国国立医学図書館(NLM)

Polycystic Kidney Disease: Unveiling the Molecular Mechanisms

Polycystic kidney disease (PKD) is a debilitating genetic disorder characterized by the formation and growth of cysts in the kidneys, ultimately leading to kidney failure. This study delves into the complex molecular mechanisms underlying PKD development. The authors provide a comprehensive overview of current knowledge, focusing on the PC1/PC2 pathways, cilia-associated mechanisms, and the role of metabolic processes, mitochondrial bioenergetics, and systemic responses in disease progression. The study aims to enhance our understanding of the intricate pathways involved in PKD, paving the way for the development of more effective treatments.

Unraveling the Complexity of PKD

This study provides a detailed look into the molecular mechanisms driving PKD development. The authors highlight the importance of understanding the interplay of various pathways, including the PC1/PC2 pathways, cilia-associated mechanisms, and metabolic and systemic factors. Imagine a vast desert landscape with interconnected oases. PKD development, like a complex desert ecosystem, involves the interplay of various factors, each contributing to the overall disease process.

Hope for New Treatments

The study emphasizes the need for continued research to develop more effective treatments for PKD. By gaining a deeper understanding of the underlying molecular mechanisms, researchers can identify new therapeutic targets and strategies to combat this debilitating disease.

Dr.Camel's Conclusion

This study underscores the importance of scientific investigation in the search for effective treatments for PKD. By understanding the complex molecular mechanisms driving this disease, we can develop new approaches to prevent, treat, and ultimately cure PKD.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-21
Further Info :

Pubmed ID

34566674

DOI: Digital Object Identifier

PMC8456103

Related Literature

SNS
PICO Info
in preparation
Languages

English

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