Paper Details 
Original Abstract of the Article :
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are approved treatments for non-small-cell lung cancer (NSCLC) patients harboring activating EGFR mutations. The EGFR C797S mutation is one of the known acquired-resistance mutations to the latest third-generation TKIs. At pre...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470952/

データ提供:米国国立医学図書館(NLM)

Fighting Lung Cancer: A Quest for a New Oasis in the Desert of Resistance

The battle against [lung cancer] is a constant struggle, much like a caravan traversing a vast and unforgiving desert. [EGFR-C797S mutation], a formidable dune in this landscape, represents a significant obstacle to effective treatment. This research, like an intrepid explorer seeking a new oasis, investigates the potential of [quercetin] to combat this resistance. The researchers explored the [cytotoxic effects of quercetin] on lung cancer cells harboring this specific mutation, examining its ability to [inhibit tumor growth] and potentially enhance the effectiveness of existing therapies.

Quercetin: A Potential Oasis in the Desert of Resistance

The study found that [quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation], suggesting its potential as a novel treatment strategy. The fact that [quercetin inhibited the tumor growth of xenografted NSCLC cells harboring the EGFR C797S mutation] is particularly encouraging, providing evidence for its effectiveness in a living model. This finding is like discovering a hidden oasis in the desert, offering hope for a new path forward in the fight against this resistant form of lung cancer.

Navigating the Desert of Lung Cancer Treatment

This research offers a beacon of hope in the desert of lung cancer treatment. The potential of quercetin to overcome resistance to existing therapies represents a significant breakthrough. While more research is needed, this study provides a promising direction for future research and clinical trials. Just as a camel relies on its adaptations to survive in the desert, we must continue to seek new solutions to combat this challenging disease.

Dr.Camel's Conclusion

This research provides a promising new path in the fight against lung cancer, particularly against EGFR-C797S mutation, a major obstacle to effective treatment. Quercetin's ability to inhibit tumor growth in both cell culture and animal models offers hope for a new oasis in the desert of resistance. Like a camel navigating the shifting sands of the desert, researchers continue to adapt and seek new solutions to this challenging disease.

Date :
  1. Date Completed 2022-01-13
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

34572484

DOI: Digital Object Identifier

PMC8470952

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Languages

English

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