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Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin.
Author: ChenChi-Yuan, ChenChin-Chuan, HuangKuo-Yen, JhongCai-Ling, LeuYann-Lii, LiHsin-Jung, WangTong-Hong
Original Abstract of the Article :
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are approved treatments for non-small-cell lung cancer (NSCLC) patients harboring activating EGFR mutations. The EGFR C797S mutation is one of the known acquired-resistance mutations to the latest third-generation TKIs. At pre...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470952/
データ提供:米国国立医学図書館(NLM)
Fighting Lung Cancer: A Quest for a New Oasis in the Desert of Resistance
The battle against [lung cancer] is a constant struggle, much like a caravan traversing a vast and unforgiving desert. [EGFR-C797S mutation], a formidable dune in this landscape, represents a significant obstacle to effective treatment. This research, like an intrepid explorer seeking a new oasis, investigates the potential of [quercetin] to combat this resistance. The researchers explored the [cytotoxic effects of quercetin] on lung cancer cells harboring this specific mutation, examining its ability to [inhibit tumor growth] and potentially enhance the effectiveness of existing therapies.
Quercetin: A Potential Oasis in the Desert of Resistance
The study found that [quercetin exhibited potent cytotoxic effects on NSCLC cells harboring the EGFR C797S mutation], suggesting its potential as a novel treatment strategy. The fact that [quercetin inhibited the tumor growth of xenografted NSCLC cells harboring the EGFR C797S mutation] is particularly encouraging, providing evidence for its effectiveness in a living model. This finding is like discovering a hidden oasis in the desert, offering hope for a new path forward in the fight against this resistant form of lung cancer.
Navigating the Desert of Lung Cancer Treatment
This research offers a beacon of hope in the desert of lung cancer treatment. The potential of quercetin to overcome resistance to existing therapies represents a significant breakthrough. While more research is needed, this study provides a promising direction for future research and clinical trials. Just as a camel relies on its adaptations to survive in the desert, we must continue to seek new solutions to combat this challenging disease.
Dr.Camel's Conclusion
This research provides a promising new path in the fight against lung cancer, particularly against EGFR-C797S mutation, a major obstacle to effective treatment. Quercetin's ability to inhibit tumor growth in both cell culture and animal models offers hope for a new oasis in the desert of resistance. Like a camel navigating the shifting sands of the desert, researchers continue to adapt and seek new solutions to this challenging disease.
Date :
- Date Completed 2022-01-13
- Date Revised 2022-12-07
Further Info :
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