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Rapid Progress in the Use of Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma.

Author: CharlińskiGrzegorz, JurczyszynArtur, VesoleDavid H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Immunomodulatory drugs (IMiDs) like thalidomide, lenalidomide, and pomalidomide have significantly improved outcomes for multiple myeloma (MM) patients. These drugs target the cereblon (CRBN) protein, altering the function of the CRBN E3 ubiquitin ligase complex, leading to the breakdown of Ikaros and Aiolos proteins. IMiDs have proven beneficial in extending progression-free and overall survival in patients with newly diagnosed, post-transplant, and relapsed/refractory MM. Thalidomide, due to side effects, is less frequently used. Lenalidomide, with a better safety profile, is employed at all stages of MM treatment, often in combination with proteasome inhibitors and monoclonal antibodies. Pomalidomide is reserved for relapsed/refractory MM, also with PIs and monoclonal antibodies. Current research is focused on the development of IMiD derivatives, known as CRBN E3 ligase modulators (CELMoDs). This review highlights the significant impact of IMiDs in MM treatment.
Paper Details　
Original Abstract of the Article :
Over the past two decades, the improvement in our understanding of the biology of MM and the introduction of new drug classes, including immunomodulatory drugs (IMiDs), proteasome inhibitors (PI), and monoclonal antibodies (MoAb), have significantly improved outcomes. The first IMiD introduced to tr...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468542/

データ提供：米国国立医学図書館（NLM）

Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma

Multiple myeloma, a type of blood cancer, is like a scorching desert wind that relentlessly attacks the body's immune system. This study explores the progress made in the treatment of multiple myeloma, focusing on the development and use of immunomodulatory drugs (IMiDs) and cereblon E3 ligase modulators (CELMoDs). Researchers delve into the history of these drugs, examining their mechanisms of action and their impact on patient outcomes.

A New Era in Multiple Myeloma Treatment

The study highlights the significant advancements in the treatment of multiple myeloma over the past two decades, driven by the development of new drug classes, including IMiDs, proteasome inhibitors (PIs), and monoclonal antibodies (MoAb). The introduction of IMiDs has brought about a transformative shift in treatment strategies, providing new weapons against this formidable disease. It's like discovering a hidden spring in the desert, a source of hope and healing for those battling this cancer.

The Promise of CELMoDs

The study explores the potential of CELMoDs, a new generation of IMiD derivatives, as promising therapeutic options for multiple myeloma. These drugs target the cereblon protein, disrupting the cancer's growth and survival pathways. It's like building a sandcastle that can withstand the harsh desert winds, a new approach that could significantly improve patient outcomes.

Dr.Camel's Conclusion

This study underscores the remarkable progress made in the treatment of multiple myeloma. The development of IMiDs and the emergence of CELMoDs offer new hope for patients, providing a beacon of light in the challenging desert of cancer treatment. The study highlights the ongoing quest for innovative therapies, fueled by a deep understanding of the disease's biology and a commitment to improving patient lives.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

34572892

DOI: Digital Object Identifier

PMC8468542

SNS
PICO Info
in preparation
Languages

English

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