Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.

Author: FioccoM F, GrootenhuisM A, PietersR, PluijmS M F, VerwaaijenE J, van HulstA M, van den AkkerE L T, van den Heuvel-EibrinkM M

Overview

Dexamethasone, a highly effective treatment for pediatric acute lymphoblastic leukemia (ALL), can induce serious neurobehavioral side effects, impacting health-related quality of life (HRQoL). Previous studies suggest that these side effects may be related to cortisol depletion of the mineralocorticoid receptor in the brain. This study aims to replicate the findings of a previous trial, which suggested that adding physiological hydrocortisone during dexamethasone treatment could alleviate these neurobehavioral problems.

Paper Details　

Original Abstract of the Article :

Dexamethasone, a highly effective drug in treating pediatric acute lymphoblastic leukemia (ALL), can induce serious neurobehavioral side effects. These side effects are experienced by patients and parents as detrimental with respect to health related quality of life (HRQoL). Based on previous studie...See full text at original site

Dr.Camel's Paper Summary Blog

Dexamethasone-Induced Neurobehavioral Side Effects: A Study Protocol for a Randomized Controlled Trial

Dexamethasone, a powerful steroid medication commonly used in the treatment of pediatric acute lymphoblastic leukemia (ALL), can induce significant neurobehavioral side effects. These side effects can negatively impact the quality of life for both patients and their families. This study protocol outlines a double-blind, placebo-controlled, randomized intervention study designed to evaluate the efficacy of hydrocortisone in mitigating dexamethasone-induced neurobehavioral side effects. The researchers hypothesize that hydrocortisone, a naturally occurring hormone, may help to counteract the neurobehavioral effects of dexamethasone by replenishing cortisol levels in the brain.

The study aims to replicate the findings of a previous trial that suggested the potential benefits of hydrocortisone in managing dexamethasone-induced neurobehavioral problems. This research could lead to a significant improvement in the well-being of children undergoing ALL treatment.

Understanding Dexamethasone Side Effects: A Journey Through the Desert of Treatment

Imagine a long and arduous journey through a desert, where the sun's heat can be unrelenting. Dexamethasone, like a powerful but potentially harsh drug, can be a vital tool for treating leukemia, but it can also have unpleasant side effects, leaving patients feeling vulnerable and uncomfortable. This research, like a skilled caravan leader seeking to minimize the risks of this journey, explores ways to mitigate these side effects and ensure the comfort and well-being of patients.

Dr. Camel's Conclusion

This study protocol presents a promising approach to addressing the neurobehavioral side effects associated with dexamethasone treatment for pediatric ALL. By investigating the potential benefits of hydrocortisone, the researchers aim to enhance the overall well-being of these young patients, minimizing the burden of these side effects and improving their quality of life.