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Efficacy of low dose combination analgesics: acetaminophen/codeine, aspirin/butalbital/caffeine/codeine, and placebo in oral surgery pain.
Author: CooperS A, DesjardinsP J, FinizioT
Original Abstract of the Article :
A double-blind, randomized, single-dose study was performed to compare the efficacy and safety of two commonly prescribed combination analgesic products to placebo. The combinations were acetaminophen 300 mg/codeine 30 mg(†), and aspirin 325 mg/butalbital 50 mg/caffeine 40 mg/codeine 30 mg(††). One ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175477/
データ提供:米国国立医学図書館(NLM)
Pain Relief After Oral Surgery: Finding the Right Combination
Oral surgery, while necessary, often comes with the unpleasant side effect of pain. This research examines the efficacy of two commonly prescribed combination analgesic products, acetaminophen/codeine and aspirin/butalbital/caffeine/codeine, in alleviating pain after oral surgery.
The authors conducted a double-blind, randomized, single-dose study to compare the effectiveness of these combinations to placebo in 123 oral surgery outpatients experiencing moderate to severe pain. They found that the aspirin/butalbital/caffeine/codeine combination was significantly more effective than placebo for total pain relief, peak relief, and global evaluation. While the acetaminophen/codeine combination was numerically superior to placebo, it achieved statistical significance only for global evaluation. Both active treatment groups experienced significantly less total anxiety than did the placebo group.
Decoding the Pain Relief Puzzle
This study provides valuable insights into the effectiveness of commonly prescribed combination analgesics for post-oral surgery pain. The findings suggest that the aspirin/butalbital/caffeine/codeine combination offers a more effective pain relief option than placebo. However, the authors acknowledge that further research is needed to understand the optimal dosing strategies and individual patient needs.
Finding Relief After Oral Surgery
For patients undergoing oral surgery, this research provides valuable information to discuss with their healthcare provider. While the aspirin/butalbital/caffeine/codeine combination appears to offer greater pain relief, it is essential to discuss the potential risks and benefits of different medications with your doctor. An individualized approach, tailored to your specific needs and preferences, is essential for achieving optimal pain management.
Dr.Camel's Conclusion
This research, like a map through the desert of post-oral surgery pain, offers valuable insights into the effectiveness of different analgesic combinations. While the aspirin/butalbital/caffeine/codeine combination appears to be a more effective option, it's essential to remember that each patient's experience with pain is unique and requires a tailored approach. Open communication with your healthcare provider is crucial to finding the best pain relief solution for your individual needs.
Date :
- Date Completed 1986-09-19
- Date Revised 2020-12-09
Further Info :
Related Literature
English
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