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The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.

Author: ArastehfarAmir, CornelyOliver A, EggerMatthias, HoeniglMartin, JenksJeffrey D, KrauseRobert, Lass-FlörlCornelia, PrattesJuergen, SpecAndrej, SpruteRosanne, ThompsonGeorge R, WiederholdNathan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

New antifungal drugs are needed to address the growing threat of drug-resistant fungal infections. This review highlights the most promising new antifungal drugs in development, including fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin. These drugs have different mechanisms of action and pharmacokinetic profiles.
Paper Details　
Original Abstract of the Article :
The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture. Limited antifungal therapeutic options are further cha...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501344/

データ提供：米国国立医学図書館（NLM）

The Antifungal Pipeline: New Oases in the Desert of Fungal Infections

Fungal infections are a growing threat, much like a desert sandstorm, with their ability to adapt and resist treatment. This review explores the antifungal pipeline, highlighting the most promising new drugs in development. The authors provide a comprehensive overview of the mechanisms of fungal resistance and the novel drug classes that are poised to revolutionize antifungal therapy. They examine the mechanisms of action, pharmacokinetic profiles, and spectrum of activity for these promising agents, offering a roadmap for the future of antifungal treatment.

Navigating the Desert of Antifungal Resistance: A New Era of Therapeutic Options

This review provides a timely and comprehensive overview of the antifungal pipeline, highlighting the exciting new drug classes that are in late-stage clinical development. The authors delve into the mechanisms of action and potential benefits of these novel agents, offering hope for the future of antifungal therapy. This research underscores the importance of ongoing research and development in the fight against fungal infections, especially in the face of increasing drug resistance.

A Camel's Takeaway: The Importance of Innovation in the Fight Against Fungal Infections

The desert of fungal infections is vast and ever-evolving, but this review provides a valuable oasis of knowledge. The authors highlight the exciting new drugs in development, offering hope for the future of antifungal therapy. This research underscores the importance of embracing innovation and exploring new avenues for managing these challenging infections.

Dr.Camel's Conclusion

This review describes the mechanisms of drug resistance employed by fungi and extensively discusses the most promising drugs in development, including fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin. The authors focus on the mechanism of action and pharmacokinetics, as well as the spectrum of activity and stages of clinical development. They also highlight the potential future role of these drugs and unmet needs.

Date :
  1. Date Completed 2022-02-04
  2. Date Revised 2022-02-18
Further Info :

Pubmed ID

34626339

DOI: Digital Object Identifier

PMC8501344

Related Literature

Article Analysis
・Effects of ibrexafungerp
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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