[Adrenal crisis associated with modafinil use].

Author: AquinosBrenda M, CanterosTeresa M, Fainstein-DayPatricia, García ArabehetyJulia, ScibonaPaula, de MiguelValeria

Paper Details 
Original Abstract of the Article :
Adrenal crisis is the most extreme presentation form of adrenal insufficiency and represents a life-threatening endocrinological emergency. This situation can be triggered by different causes including the use of CYP3A4-inducing drugs, which accelerate hydrocortisone clearance. We describe the case ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/34633961

データ提供:米国国立医学図書館(NLM)

Modafinil and Adrenal Crisis: A Case Study

This case study takes us on a journey through the delicate balance of [adrenal crisis] and the impact of certain medications. It's like a camel navigating a path through the scorching desert of hormonal imbalances, where even small changes can have significant consequences.

Modafinil: A Potential Trigger in the Desert of Adrenal Insufficiency

The study presents the case of an elderly woman with [secondary adrenal insufficiency] who experienced symptoms consistent with [adrenal crisis] after starting modafinil treatment. It's like a camel encountering a hidden hazard in the desert, a potential trigger for a dangerous reaction. The researchers suggest that modafinil may have precipitated the symptoms of adrenal insufficiency by [increasing the steroid clearance], like a sudden shift in the desert landscape.

Navigating the Desert of Adrenal Insufficiency: A Cautionary Tale

This case study serves as a stark reminder of the potential risks associated with certain medications, particularly for individuals with pre-existing conditions like adrenal insufficiency. It's like a camel navigating a treacherous terrain, where even a slight deviation from the path can lead to unexpected consequences. The study highlights the importance of careful monitoring and dose adjustment for patients taking medications that can affect the metabolism of corticosteroids.

Dr.Camel's Conclusion

This case study reveals the potential risks associated with the use of modafinil in individuals with adrenal insufficiency. The researchers underscore the importance of careful monitoring and dose adjustment for patients taking medications that can influence steroid metabolism. It's a valuable lesson for clinicians and patients alike, reminding us to tread carefully through the desert of medication interactions, where even seemingly harmless medications can have significant consequences. This case study is a reminder to always consult with a healthcare professional before starting any new medication and to stay vigilant about potential interactions and side effects.

Date :
  1. Date Completed 2021-10-13
  2. Date Revised 2021-10-13
Further Info :

Pubmed ID

34633961

DOI: Digital Object Identifier

34633961

Related Literature

SNS
PICO Info
in preparation
Languages

Spanish

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