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Fenofibrate ameliorates olanzapine's side effects without altering its central effect: emphasis on FGF-21-adiponectin axis.

Author: AliAzza A, El-BaklyWesam M, El-DemerdashEbtehal, El-KilanySara S, GalalAya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated whether fenofibrate could ameliorate olanzapine's deleterious effect on insulin resistance in postweaning socially isolated reared female rats. The study found that fenofibrate significantly reduced weight gain, adiposity index, insulin resistance, and lipid profile in rats treated with olanzapine.
Paper Details　
Original Abstract of the Article :
The present work was designed to investigate whether fenofibrate could ameliorate olanzapine deleterious effect on insulin resistance via its effect on fibroblast growth factor-21 (FGF-21)-adiponectin axis without affecting olanzapine antipsychotic effect in postweaning socially isolated reared fema...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34637209

データ提供：米国国立医学図書館（NLM）

Fenofibrate: A Potential Oasis in the Desert of Olanzapine Side Effects

The [treatment of mental health disorders] often involves [medications] that can have [undesirable side effects]. This study investigates the [potential benefits of fenofibrate] in [ameliorating the side effects of olanzapine] in [postweaning socially isolated rats]. Olanzapine, an [antipsychotic medication], can cause [insulin resistance], [weight gain], and [metabolic disturbances]. Researchers found that [fenofibrate effectively reduced olanzapine-induced insulin resistance] and [improved lipid profile] without [affecting olanzapine's antipsychotic effect].

Fenofibrate: A Potential Solution for Olanzapine Side Effects

This study suggests that [fenofibrate] could be a [valuable adjunct therapy] for [patients taking olanzapine]. Its ability to [reduce insulin resistance] and [improve metabolic health] without [compromising olanzapine's efficacy] offers a [potential pathway] to [better management] of [olanzapine-related side effects].

Navigating the Desert of Mental Health Medications: Considerations for Patients

If you are taking [olanzapine] and experiencing [side effects], it is important to [discuss your concerns] with your doctor. [Open communication] and [close monitoring] are essential for [optimizing your treatment] and [managing any potential risks].

Dr.Camel's Conclusion

The desert of mental health medications can be challenging to navigate. This study explores a potential oasis in the form of fenofibrate. We hope that this research will lead to [improved outcomes] for patients seeking [effective and well-tolerated treatment] for their [mental health conditions].

Date :
  1. Date Completed 2022-02-24
  2. Date Revised 2023-09-10
Further Info :

Pubmed ID

34637209

DOI: Digital Object Identifier

00008877-202112000-00002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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