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Application of armodafinil-loaded microneedle patches against the negative influence induced by sleep deprivation.

Author: DuLina, JinYiguang, LiQian, OuGe, WangLin, YuXiang, ZhangShouguo, ZhangYuanyuan, ZhuLin, ZhuSiqing, ZhuangXiaomei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Sleep deprivation can significantly impair cognition, highlighting the need for effective interventions. Armodafinil is a wake-promoting agent used to counter sleep deprivation-related disorders. This study reports the development of a novel armodafinil microneedle patch formulation. Armodafinil-loaded microneedles, fabricated using polyvinylpyrrolidone (PVP) K90, exhibited high mechanical strength, allowing for skin penetration and drug release. The microneedle formulation demonstrated sustained blood armodafinil levels compared to oral administration. In vivo studies showed that armodafinil microneedles effectively improved cognitive function in sleep-deprived mice.
Paper Details　
Original Abstract of the Article :
Cognition maintenance is essential for healthy and safe life if sleep deprivation happens. Armodafinil is a wake-promoting agent against sleep deprivation related disorders. However, only the tablet formulation is available, which may limit its potential in some circumstances. Here, we report the sy...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2021.10.009

データ提供：米国国立医学図書館（NLM）

Armodafinil: A Beacon of Hope in the Desert of Sleep Deprivation

Sleep deprivation, a common problem in today's fast-paced world, can have significant negative impacts on cognition and overall health. It's like navigating a desert with a fading compass, making it difficult to find your way. Armodafinil, a wake-promoting agent, offers a potential solution for managing sleep deprivation and preserving cognitive function. This study explores the use of armodafinil-loaded microneedle patches for transdermal delivery, aiming to improve convenience and effectiveness in treating sleep deprivation.

A New Oasis for Sleep Deprivation: Microneedle Patches for Armodafinil Delivery

The study found that armodafinil-loaded microneedle patches effectively delivered the drug transdermally, achieving more lasting and stable blood concentrations compared to oral administration. This approach shows promise for improving the convenience and effectiveness of armodafinil therapy, offering a potential oasis for those struggling with sleep deprivation. It's like discovering a new source of water in the desert, providing a reliable and sustainable solution for hydration.

Navigating the Desert of Sleep Deprivation: A New Approach to Cognitive Preservation

The research offers a new perspective on managing sleep deprivation, exploring the potential of microneedle patches for transdermal drug delivery. This approach could offer a more convenient and effective way to maintain cognitive function, providing a valuable tool for individuals facing the challenges of sleep deprivation. It's like equipping travelers with a new and improved compass, allowing them to navigate the desert of sleep deprivation with greater clarity and precision.

Dr.Camel's Conclusion

Sleep deprivation can be a formidable desert, challenging our cognitive abilities and impacting our well-being. This research explores a new approach to combatting this challenge, using armodafinil-loaded microneedle patches for transdermal delivery. This innovative approach offers a potential oasis, providing a convenient and effective way to manage sleep deprivation and preserve cognitive function. It's a reminder that even in the face of adversity, we can find new paths to recovery and well-being, making the journey through the desert of sleep deprivation more manageable.
Date :
  1. Date Completed 2022-03-11
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

34700002

DOI: Digital Object Identifier

10.1016/j.ejpb.2021.10.009

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Languages

English

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