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GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA<sub>A</sub> receptors.

Author: CerneRok, CookJames M, GolaniLalit K, JinXiaoming, LippaArnold, PingXingjie, PoeMichael M, SmithJodi L, WitkinJeffrey M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review examines the therapeutic potential of positive allosteric modulators of GABA<sub>A</sub> receptors (GABAkines) in treating neurological and psychiatric disorders. While traditional GABAkines like diazepam have safety concerns, newer compounds like neuroactive steroids and imidazodiazepines are being investigated for their potential to provide safer and more effective treatment options for conditions such as epilepsy, anxiety, and depression.
Paper Details　
Original Abstract of the Article :
Positive allosteric modulators of &#947;-aminobutyric acid-A (GABA<sub>A</sub>) receptors or GABAkines have been widely used medicines for over 70&#160;years for anxiety, epilepsy, sleep, and other disorders. Traditional GABAkines like diazepam have safety and tolerability concerns that include seda...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34793859

データ提供：米国国立医学図書館（NLM）

GABAA Receptor Modulation: A New Frontier in Neuroscience

In the vast desert of the brain, a complex network of neurotransmitters and receptors governs our thoughts, emotions, and behaviors. This research delves into the exciting world of GABAkines, a class of drugs that modulate GABAA receptors, playing a crucial role in regulating neuronal activity. The study explores the potential of GABAkines in treating various neurological and psychiatric disorders, while acknowledging the challenges associated with their safety and tolerability. The authors highlight the promising developments of newer GABAkines, such as neuroactive steroids and selective GABAkines, which aim to address these challenges and offer more targeted therapeutic approaches.

The Promise of GABAkines: A New Oasis in the Desert of Neurological Disorders

This research unveils a new oasis of potential in the desert of neurological and psychiatric disorders. The development of safer and more effective GABAkines offers a glimmer of hope for patients suffering from epilepsy, anxiety, sleep disorders, and other conditions. This innovative approach holds the potential to revolutionize the treatment landscape, providing relief and improved quality of life for countless individuals.

Navigating the Complexities of the Brain: A Doctor's Perspective

The study underscores the importance of understanding the intricate workings of the brain and the role of GABAA receptors in maintaining neuronal balance. Like a skilled desert explorer, a doctor must navigate the complex terrain of neurological disorders, carefully considering the potential benefits and risks of various treatments. This meticulous approach, guided by scientific understanding and compassion, is crucial for providing patients with the best possible care.

Dr. Camel's Conclusion

This research delves into the fascinating world of GABAkines, highlighting the potential of these drugs to treat a wide range of neurological and psychiatric disorders. The study emphasizes the importance of ongoing research to develop safer and more effective GABAkines, paving the way for improved treatment options and a brighter future for patients.
Date :
  1. Date Completed 2022-05-17
  2. Date Revised 2023-06-02
Further Info :

Pubmed ID

34793859

DOI: Digital Object Identifier

NIHMS1756985

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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