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Nephrotoxicity in advanced thyroid cancer treated with tyrosine kinase inhibitors: An update.

Author: ArvatEmanuela, BianconeLuigi, GalloMarco, ManganaroMarco, MellaAlberto, NervoAlice, PiovesanAlessandro, RagniAlberto, RettaFrancesca

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of advanced thyroid cancer patients. However, proteinuria, a common side effect of TKIs such as lenvatinib and cabozantinib, can negatively impact renal function and quality of life. This review provides a comprehensive overview of the pathogenesis, risk factors, diagnosis, and management of TKIs-related renal adverse events in thyroid cancer patients.
Paper Details　
Original Abstract of the Article :
Over the past decade, the prognosis of advanced thyroid cancer (TC) patients has dramatically improved thanks to the introduction of tyrosine kinase inhibitors (TKIs). Despite their effectiveness, these drugs are burdened with several side effects that can negatively affect quality of life and compr...See full text at original site
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引用元：
https://doi.org/10.1016/j.critrevonc.2021.103533

データ提供：米国国立医学図書館（NLM）

Nephrotoxicity in Advanced Thyroid Cancer Treated with Tyrosine Kinase Inhibitors

Advanced thyroid cancer, like a relentless desert sandstorm, can be a challenging foe. Tyrosine kinase inhibitors (TKIs) have emerged as powerful weapons in the fight against this disease, but their effectiveness comes at a price. This review examines the nephrotoxicity associated with TKI treatment, focusing on the common side effect of proteinuria. Researchers delve into the potential mechanisms underlying this toxicity and provide insights into its diagnosis and management. They emphasize the importance of early recognition and appropriate interventions to minimize renal dysfunction and prevent life-threatening complications.

Managing the Side Effects of TKI Treatment

This review provides a comprehensive overview of nephrotoxicity associated with TKI treatment for advanced thyroid cancer. It highlights the importance of monitoring renal function and identifying potential risk factors to effectively manage this side effect. It's like having a skilled guide to navigate the potential hazards of TKI treatment, ensuring optimal patient outcomes and minimizing potential risks.

Protecting Renal Health

This research emphasizes the importance of carefully managing nephrotoxicity associated with TKI treatment for advanced thyroid cancer. Early recognition, appropriate monitoring, and timely intervention are crucial for protecting renal function and minimizing the risk of long-term complications. It's like providing a protective shield to safeguard the kidneys from the potential damaging effects of these powerful medications.

Dr.Camel's Conclusion

This review is a valuable resource for understanding and managing nephrotoxicity associated with TKI treatment for advanced thyroid cancer. It underscores the importance of a multidisciplinary approach to patient care, ensuring that renal health is closely monitored and addressed promptly. It's a reminder that navigating the challenges of cancer treatment requires a comprehensive and proactive approach to ensure optimal patient outcomes.

Date :
  1. Date Completed 2021-12-09
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

34801702

DOI: Digital Object Identifier

10.1016/j.critrevonc.2021.103533

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・Side Effects of cabozantinib (thyroid cancer)
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PICO Info
in preparation
Languages

English

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