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3D Printing of Tricalcium Phosphate/Poly Lactic-co-glycolic Acid Scaffolds Loaded with Carfilzomib for Treating Critical-sized Rabbit Radial Bone Defects.

Author: ChenJian, DengGuangfeng, DongShujun, HuangGege, HuangKe, LiFeng, LiKai, LiYe, LiuJia, LuQiaoyan, TangYujin, WangChong, WangLiqiang, XieKegong, YangChengliang, ZhengChuanchuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study presents a novel 3D-printed scaffold loaded with carfilzomib (CFZ), a clinically approved proteasome inhibitor, to promote bone regeneration. The CFZ-loaded scaffold successfully promoted osteogenesis and angiogenesis while inhibiting osteoclastogenesis in a rabbit model of bone defect. These findings suggest that this scaffold could be a promising treatment option for critical-sized bone defects.
Paper Details　
Original Abstract of the Article :
The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication of advanced scaffolds and the use of newly discovered functional drugs. As the creation of new drugs and their clinical approval often cost a long time and billions of U.S. dollars, producing scaffolds...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8600297/

データ提供：米国国立医学図書館（NLM）

3D Printing of Tricalcium Phosphate/Poly Lactic-co-glycolic Acid Scaffolds for Treating Critical-sized Bone Defects

The field of bone tissue engineering is a desert of innovation, constantly evolving with new tools and techniques. This research investigates the use of 3D-printed scaffolds loaded with carfilzomib, a repurposed drug originally used for multiple myeloma, to treat critical-sized bone defects. The researchers meticulously designed and tested these scaffolds, much like a camel caravan carefully planning its route across a challenging desert landscape.

The study found that the 3D-printed scaffolds loaded with carfilzomib promoted bone formation and angiogenesis, the growth of new blood vessels, in a rabbit model of critical-sized bone defects. This discovery is like finding a hidden oasis in the desert, offering a promising solution for treating bone defects. It highlights the potential of 3D printing and drug repurposing to advance bone tissue engineering and improve bone regeneration.

A New Frontier in Bone Tissue Engineering

This study reveals the potential of 3D printing and drug repurposing to revolutionize bone tissue engineering. It highlights the ability of 3D-printed scaffolds loaded with repurposed drugs to promote bone regeneration and accelerate healing. This is like discovering a new and more efficient way to navigate a desert landscape, offering a promising path towards bone regeneration and improved outcomes for patients with bone defects.

Health Implications and Lifestyle Applications

This study offers hope for individuals with bone defects. It suggests that 3D-printed scaffolds loaded with repurposed drugs could provide a new and effective treatment option, accelerating healing and improving overall health. It's like finding a hidden oasis in the desert, offering a source of strength and vitality to aid in the process of healing.

Dr.Camel's Conclusion

This research is a testament to the innovative spirit of medical science. It showcases the potential of 3D printing and drug repurposing to advance bone tissue engineering and improve the lives of individuals with bone defects. It's like finding a new oasis in the desert of medical research, offering a promising path towards improved bone regeneration and a brighter future for patients with bone defects.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-11-23
Further Info :

Pubmed ID

34805594

DOI: Digital Object Identifier

PMC8600297

Related Literature

Article Analysis
・Side Effects of bortezomib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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