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Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation.
Author: GuptaVivek, KulkarniNishant S, KundaNitesh K, PatilSuyash M, SawantShruti S, ShuklaSnehal K
Original Abstract of the Article :
Osimertinib (OB) is a third-generation irreversible tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR), overexpressed in non-small cell lung cancer. Systemic administration of drug often results in poor drug levels at the primary tumor in the lungs and is associated with...See full text at original site
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引用元:
https://doi.org/10.1007/s13346-021-01088-0
データ提供:米国国立医学図書館(NLM)
Osimertinib Liposomes: Delivering Cancer Treatment Straight to the Source
The field of cancer treatment is constantly evolving, and this research delves into a promising new approach for treating non-small cell lung cancer. Imagine a caravan traversing a vast desert, where the journey is long and the resources are scarce. In this case, the caravan represents osimertinib, a powerful drug, and the desert is the human body, where it's challenging to deliver the medicine effectively to the targeted tumor in the lungs.
To improve delivery and minimize systemic side effects, the authors have developed inhalable liposomes that carry osimertinib directly to the tumor site. These liposomes act like sturdy camels, capable of carrying valuable cargo (osimertinib) across the vast desert of the lungs. The results were impressive, with the liposomes demonstrating excellent aerosolization performance and effectively reducing the tumor cell migration and growth.
A New Route for Lung Cancer Treatment: Targeting and Efficiency
The researchers showed that the inhalable osimertinib liposomes achieved a higher encapsulation rate compared to traditional methods, suggesting a more efficient way to deliver the drug. The liposomes also significantly reduced tumor cell migration and growth in laboratory tests, highlighting their potential to improve treatment outcomes.
A More Targeted Approach to Lung Cancer: Minimizing Side Effects
This study suggests that inhalable osimertinib liposomes could offer a more targeted and effective approach to treating lung cancer. By delivering the drug directly to the tumor site, they could potentially reduce systemic side effects and improve patient outcomes. It's like finding a shortcut across the desert, reaching the destination faster and with less strain on the traveler.
Dr.Camel's Conclusion
This research offers hope for a more targeted and efficient approach to treating lung cancer. The use of inhalable liposomes may provide a more effective way to deliver cancer-fighting drugs, potentially improving outcomes and reducing side effects. It's a reminder that even in the vast desert of cancer research, innovation and creativity can lead to new pathways for healing.
Date :
- Date Completed 2022-09-13
- Date Revised 2022-09-21
Further Info :
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