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Neuroprotective Effects of Fingolimod in a Cellular Model of Optic Neuritis.

Author: AdilMir S, AlfarhanMoaddey, CandadaiAmritha A, FaganSusan C, LiuFang, NarayananS Priya, SomanathPayaningal R, VermaArti

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Optic neuritis (ON) is a common neurological manifestation of multiple sclerosis (MS), leading to visual dysfunction and neuronal damage. This study investigated the neuroprotective effects of fingolimod (FTY), an FDA-approved immunomodulatory agent for MS, in a cellular model of ON. FTY significantly reduced TNFα-induced neuronal death in R28 retinal neuronal cells. The study also showed that FTY attenuated TNFα-induced changes in cell survival and stress signaling molecules. These findings suggest that FTY has neuroprotective properties against ON-associated neuronal damage, offering potential for treating this debilitating condition.
Paper Details　
Original Abstract of the Article :
Visual dysfunction resulting from optic neuritis (ON) is one of the most common clinical manifestations of multiple sclerosis (MS), characterized by loss of retinal ganglion cells, thinning of the nerve fiber layer, and inflammation to the optic nerve. Current treatments available for ON or MS are o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616192/

データ提供：米国国立医学図書館（NLM）

Fingolimod's Neuroprotective Potential in Optic Neuritis

Optic neuritis (ON) is a common complication of multiple sclerosis (MS) that can lead to vision loss. While current treatments target the inflammatory phase, they offer limited long-term protection. This study investigates the neuroprotective properties of fingolimod (FTY), an FDA-approved immunomodulatory agent for MS therapy, in a cellular model of ON-associated neuronal damage. R28 retinal neuronal cells were exposed to tumor necrosis factor-α (TNFα) to induce neuronal damage.

Fingolimod's Neuroprotective Effects

The study found that FTY treatment significantly reduced TNFα-induced neuronal death, attenuated cell stress signaling, and promoted the expression of neuronal markers. This suggests that FTY could offer a promising neuroprotective approach for ON-associated neuronal damage.

Preserving Vision: A Potential Role for Fingolimod

This study's findings provide encouraging evidence for the neuroprotective potential of fingolimod in ON-associated neuronal damage. This opens up new possibilities for developing more effective treatments that not only target inflammation but also protect against long-term vision loss. This is like finding a hidden oasis that nourishes and revitalizes the desert landscape.

Dr. Camel's Conclusion

Similar to how a camel navigates the desert, this study explores the potential for fingolimod to protect retinal neurons from the damaging effects of optic neuritis. It offers a glimmer of hope for those seeking to preserve their vision and improve their quality of life.

Date :
  1. Date Completed 2022-01-03
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

34831161

DOI: Digital Object Identifier

PMC8616192

Related Literature

Article Analysis
・Effects of fingolimod
SNS
PICO Info
in preparation
Languages

English

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