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Construction of synergistic pH/H<sub>2</sub>O<sub>2</sub>-responsive prodrug for prolonging blood circulation and accelerating cellular internalization.

Author: LiKaipeng, LiuJun, SiShuang, XuJinyi, XuePeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study describes the development of a multifunctional doxifluridine-conjugate prodrug (LYX) for cancer treatment. This prodrug utilizes a shielding group that improves circulation and tumor accumulation while enhancing drug release efficiency. The strategy combines diagnostic and imaging capabilities with therapeutic benefits, potentially reducing side effects.
Paper Details　
Original Abstract of the Article :
We have developed a real-time and multifunctional doxifluridine-conjugate prodrug (LYX), which involved the preliminary methylfluorescein with 5-fluorouracil linker as protecting group, the targeting biotin unit, and a model therapeutic drug (doxifluridine). The shielding group (5'-DFUR) was found t...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2021.105510

データ提供：米国国立医学図書館（NLM）

A Smart Prodrug for Cancer Treatment

Cancer treatment is a challenging journey, often involving powerful drugs with potential side effects. This study introduces a novel prodrug, LYX, designed to deliver a therapeutic drug (doxifluridine) more effectively and safely. The researchers engineered LYX to respond to specific conditions within the body, releasing the drug only when and where it's needed. It's like creating a smart camel that can carry precious cargo through a harsh desert environment, releasing it only when it reaches its destination.

Targeting Cancer Cells

LYX is designed to be stable at physiological pH, but it breaks down and releases the drug in the acidic microenvironment of a tumor. This targeted delivery system allows for higher concentrations of the drug to reach the tumor cells while minimizing exposure to healthy tissues. It's like directing a caravan of camels towards a specific oasis, ensuring that the precious water reaches its intended destination. The study found that LYX was effective in prolonging circulation and improving accumulation in the acidic microenvironment of the tumor.

A New Era in Drug Delivery

This research demonstrates the potential of smart prodrugs to revolutionize drug delivery, enhancing effectiveness and minimizing side effects. It's like discovering a new and efficient way to transport valuable resources across the desert, ensuring a more efficient and sustainable journey. This approach could lead to a new era in cancer treatment, offering a more targeted and safer way to combat this devastating disease.

Dr.Camel's Conclusion

This research offers a promising glimpse into the future of drug delivery, showcasing the potential of smart prodrugs to improve treatment outcomes while minimizing side effects. This innovation could revolutionize the way we approach cancer treatment, leading to a more targeted and effective journey for patients.

Date :
  1. Date Completed 2022-02-18
  2. Date Revised 2022-02-18
Further Info :

Pubmed ID

34847429

DOI: Digital Object Identifier

10.1016/j.bioorg.2021.105510

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Languages

English

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