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Intra-articular delivery of full-length antibodies through the use of an in situ forming depot.
Author: BossisGuillaume, ConstantinidesMichael, Fayd'herbe De MaudaveAlexis, GrizotSylvestre, HirtzChristophe, JorgensenChristian, LeconetWilhem, Lopez-NoriegaAdolfo, Louis-PlencePascale, NoëlDaniele, ToupetKarine, VialaretJérôme, VillalbaMartin, de ToledoMarion
Original Abstract of the Article :
Monoclonal antibodies (mAbs) are large size molecules that have demonstrated high therapeutic potential for the treatment of cancer or autoimmune diseases. Despite some excellent results, their intravenous administration results in high plasma concentration. This triggers off-target effects and some...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.jconrel.2021.12.010
データ提供:米国国立医学図書館(NLM)
Monoclonal Antibodies: A Targeted Delivery System for Diseases
Monoclonal antibodies (mAbs) are powerful tools in the fight against diseases like cancer and autoimmune disorders. These antibodies act like skilled archers, precisely targeting and attacking specific cells. This research explores a novel approach for delivering mAbs directly to the affected area, bypassing systemic circulation and minimizing side effects.
The study investigates the use of an in situ forming depot technology to deliver mAbs locally. Imagine a camel carrying precious cargo across the desert, carefully protected within a sturdy container. The research aims to create a similar protective environment for mAbs, ensuring their effective delivery to the target site.
A Precise and Efficient Way to Deliver Antibodies
The in situ forming depot technology holds promise for delivering mAbs directly to the affected area, maximizing their effectiveness and minimizing systemic side effects. This is like a camel navigating a narrow passage, precisely delivering its load to a specific destination. This approach could revolutionize the way we treat diseases.
A New Era in Antibody Delivery
This research marks a significant step toward a more targeted and efficient approach to delivering mAbs. It’s like a camel discovering a shortcut through the desert, making the journey quicker and smoother. This technology has the potential to revolutionize the treatment of diseases by delivering the right medication to the right place at the right time.
Dr.Camel's Conclusion
This research, like a camel navigating a rugged terrain, highlights the power of innovation in finding new ways to deliver essential medical tools. In situ forming depot technology offers a promising approach for localized delivery of mAbs, potentially revolutionizing the treatment of various diseases.
Date :
- Date Completed 2022-03-22
- Date Revised 2022-03-22
Further Info :
Related Literature
English
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