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Clinical and psychological factors in coronary heart disease patients with statin associated muscle side-effects.

Author: DammenToril, FagerlandMorten, HusebyeEinar, KristiansenOscar, MunkhaugenJohn, PeersenKari, PerkJoep, SverreElise, VetheNils Tore

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients with confirmed statin-associated muscle symptoms (SAMS) are more likely to present with bilateral lower extremity muscle symptoms compared to those with refuted SAMS. However, psychological factors were not found to be associated with self-perceived SAMS or confirmed SAMS. Careful pain history and evaluation for alternative causes of muscle symptoms may reduce statin discontinuation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To compare clinical and psychological factors among patients with self-perceived statin-associated muscle symptoms (SAMS), confirmed SAMS, and refuted SAMS in coronary heart disease patients (CHD). METHODS: Data were obtained from a cross-sectional study of 1100 CHD outpatients and a st...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8680044/

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Statin-Associated Muscle Side Effects

Statins, commonly used to lower cholesterol, can sometimes lead to muscle side effects, making the journey to cardiovascular health a bit rougher. This study explores the factors associated with statin-associated muscle symptoms (SAMS), specifically comparing patients with self-perceived SAMS, confirmed SAMS, and refuted SAMS. The researchers conducted a cross-sectional study of 1100 patients with coronary heart disease and a randomized, double-blinded, placebo-controlled crossover study of 71 patients. The findings suggest that bilateral, symmetric muscle symptoms in the lower extremities are more prevalent in patients with confirmed SAMS compared to those with refuted SAMS. However, no significant differences were found in psychological factors between groups.

The Oasis of Communication: Navigating Muscle Symptoms

This study provides valuable insights into the characteristics of statin-associated muscle symptoms. The findings suggest that bilateral, symmetric muscle symptoms in the lower extremities are a common feature of confirmed SAMS. This information can help healthcare professionals better identify and address these symptoms, potentially reducing the risk of statin discontinuation.

Navigating the Desert of Cardiovascular Health: Seeking Personalized Care

The study's findings underscore the importance of open communication and careful monitoring when patients are taking statins. It's crucial to discuss any muscle symptoms with a healthcare professional to determine the underlying cause and to develop a personalized care plan that balances the benefits of statin therapy with the potential for side effects.

Dr.Camel's Conclusion

This research offers a valuable guide for navigating the desert of statin-associated muscle symptoms. The findings highlight the importance of attentive monitoring and open communication to ensure that patients receive the optimal cardiovascular care while minimizing the risk of muscle side effects.

Date :
  1. Date Completed 2022-01-31
  2. Date Revised 2022-01-31
Further Info :

Pubmed ID

34915854

DOI: Digital Object Identifier

PMC8680044

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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