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Pharmacokinetic and Pharmacodynamic Evaluation of Gemifloxacin Chitosan Nanoparticles As an Antibacterial Ocular Dosage Form.

Author: AliAmir I, ElDesawyEsraa M, ElShafeeyAhmed H, HassanHatem A F M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chitosan nanoparticles loaded with gemifloxacin (GM) were developed to enhance the treatment of ocular infections. The nanoparticles increased the drug concentration in both the tear and aqueous humor, leading to both superficial and deep tissue effects. The nanoparticles showed improved antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, resulting in preserved corneal histology and reduced bacterial keratitis in rabbits.
Paper Details　
Original Abstract of the Article :
Ocular infections are classified into superficial keratitis, conjunctivitis or deep infections such as corneal abscesses and blepharitis. Herein, we focused on the development of formulation approaches that could prolong the residence time of gemifloxacin (GM) and enhance its corneal penetration to ...See full text at original site
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引用元：
https://doi.org/10.1016/j.xphs.2021.12.016

データ提供：米国国立医学図書館（NLM）

Gemifloxacin Chitosan Nanoparticles: A New Approach to Treating Ocular Infections

Ocular infections, from superficial keratitis to deep corneal abscesses, can be a challenging medical issue. This research explores the potential of gemifloxacin (GM) loaded chitosan nanoparticles (NPs) as an antibacterial ocular dosage form. The researchers, like chemists creating innovative solutions for a desert community lacking clean water, formulated GM NPs to enhance the delivery and efficacy of this antibacterial agent. Their findings suggest that GM NPs significantly increased GM concentration in the eye, leading to improved antibacterial activity and preserved corneal histology. This research provides a promising new avenue for treating ocular infections with enhanced efficacy and reduced side effects.

GM NPs: A Desert Oasis for Eye Health

This study suggests that gemifloxacin (GM) loaded chitosan nanoparticles (NPs) may be a promising new approach to treating ocular infections. GM NPs significantly increased GM concentration in the eye, leading to improved antibacterial activity and preserved corneal histology. It's like discovering a desert oasis that provides not only water but also healing properties, offering a brighter outlook for eye health.

A New Era of Ocular Treatment

This research highlights the potential of nanoparticle-based delivery systems to revolutionize ocular treatment. It demonstrates that GM NPs can offer a more effective and potentially safer alternative to traditional ocular treatments. This is like a desert traveler embracing innovative technologies to overcome challenges and improve their journey.

Dr.Camel's Conclusion

This study suggests that gemifloxacin (GM) loaded chitosan nanoparticles (NPs) may be a promising new approach to treating ocular infections, offering a more effective and potentially safer alternative to traditional ocular treatments. It's like discovering a desert oasis that provides not only water but also healing properties, offering a brighter outlook for eye health.

Date :
  1. Date Completed 2022-04-20
  2. Date Revised 2022-05-16
Further Info :

Pubmed ID

34929155

DOI: Digital Object Identifier

10.1016/j.xphs.2021.12.016

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Article Analysis
・Effects of gemifloxacin
SNS
PICO Info
in preparation
Languages

English

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