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Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment.

Author: JiangYa-Jie, LiuJian, WangYe-Qing, WangYu-Hong, ZhaoHong-Qing, ZouMan-Shu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Melatonin, a hormone regulating circadian rhythm, has shown antidepressant effects through multiple mechanisms including regulation of the hypothalamic-pituitary-adrenal axis, inhibition of neuroinflammation, and promotion of neuroplasticity. Melatonin receptor agonists are also promising therapeutic agents for depression.
Paper Details　
Original Abstract of the Article :
Depression has become one of the most commonly prevalent neuropsychiatric disorders, and the main characteristics of depression are sleep disorders and melatonin secretion disorders caused by circadian rhythm disorders. Abnormal endogenous melatonin alterations can contribute to the occurrence and d...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbr.2021.113724

データ提供：米国国立医学図書館（NLM）

Melatonin: A Desert Oasis for Depression

Depression is a dark and desolate landscape, much like a vast, unforgiving desert. This study delves into the potential of melatonin, a natural hormone that regulates sleep, as a treatment for depression. The authors explore the intricate mechanisms by which melatonin exerts its antidepressant effects, like uncovering a hidden spring in the desert, promising to quench the thirst for relief.

Melatonin and Its Agonists: A Beacon of Hope

The study highlights the role of melatonin in regulating the hypothalamic-pituitary-adrenal (HPA) axis, a crucial pathway involved in stress response. The authors also discuss the potential of melatonin receptor agonists, like agomelatine and ramelteon, as promising therapeutic options for depression, like finding a caravan of camels carrying essential resources through the desert.

From Darkness to Light: A New Path to Healing

This study offers a glimmer of hope for those battling depression, suggesting that melatonin and its agonists could play a significant role in alleviating symptoms and improving quality of life. The authors emphasize the need for further research to fully understand the potential of these agents, potentially leading to novel treatments for depression and other related disorders.

Dr.Camel's Conclusion

This study explores the potential of melatonin and its agonists as novel treatments for depression, highlighting their involvement in regulating the HPA axis and promoting neuroprotection. This research opens up new avenues for exploring the therapeutic potential of these agents, offering a beacon of hope for those struggling with depression and other mood disorders.

Date :
  1. Date Completed 2022-03-10
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

34929236

DOI: Digital Object Identifier

10.1016/j.bbr.2021.113724

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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