Paper Details 
Original Abstract of the Article :
Label="INTRODUCTION" NlmCategory="BACKGROUND">Several drugs of abuse (DOA) are capable of modulating neurohypophysial hormones, such as oxytocin (OT) and vasopressin (VP), potentially resulting in the development of psychological abnormalities, such as cognitive dysfunction, psychoses, and affective...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664698/

データ提供:米国国立医学図書館(NLM)

Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats

This study investigates the potential impact of [エファビレンツ] exposure on [オキシトシン] and [バソプレシン] levels in rats. The authors found that prolonged exposure to efavirenz reduced peripheral oxytocin and vasopressin levels, similar to the effects of known drugs of addiction. This finding suggests that efavirenz may have similar addictive properties to known drugs of abuse, highlighting the need for further research into its potential neuropsychiatric effects.

A Desert Mirage of Addiction

This study reveals a concerning finding - prolonged exposure to efavirenz, a medication commonly used to treat HIV, may have similar addictive properties to known drugs of abuse. The study found that efavirenz reduced peripheral oxytocin and vasopressin levels, similar to the effects of drugs like THC, methamphetamine, and cocaine. This discovery is a wake-up call, highlighting the importance of understanding the potential long-term consequences of efavirenz use.

Navigating the Complex Terrain of HIV Treatment

The treatment of HIV is like navigating a complex and often challenging desert. This study underscores the need for comprehensive understanding of the potential side effects of medication, such as efavirenz. The findings raise important questions about the long-term effects of efavirenz on the brain and behavior, and highlight the importance of continued research to ensure the safety and well-being of patients.

Dr.Camel's Conclusion

This study presents compelling evidence that prolonged exposure to efavirenz may have similar addictive properties to known drugs of abuse. The findings highlight the importance of continued research into the potential neuropsychiatric effects of efavirenz. It serves as a reminder that even seemingly safe medications can have unforeseen consequences, and careful monitoring and research are crucial to ensuring the safety and well-being of patients.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-29
Further Info :

Pubmed ID

34939063

DOI: Digital Object Identifier

PMC8664698

Related Literature

SNS
PICO Info
in preparation
Languages

English

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