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The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson's Disease - An Update.

Author: ChewZhi Xin, ChyeSoi Moi, KohRhun Yian, LimChooi Ling, LingAnna Pick Kiong, NgKhuen Yen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

MAO-B inhibitors are used to treat Parkinson's disease by preventing the breakdown of dopamine. Selegiline and rasagiline are effective inhibitors, while safinamide is a newer agent with both dopaminergic and non-dopaminergic mechanisms. MAO-B inhibitors may also have neuroprotective effects, but more research is needed.
Paper Details　
Original Abstract of the Article :
Parkinson's disease (PD) is a progressive neurodegenerative disease characterised by reduced dopamine levels in the substantial nigra. This may lead to typical motor features such as bradykinesia, resting tremors and rigid muscles, as well as non-motor symptoms such as neuropsychiatric symptoms, sle...See full text at original site
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引用元：
https://doi.org/10.2174/1871527321666211231100255

データ提供：米国国立医学図書館（NLM）

Monoamine Oxidase B Inhibitors: A New Frontier in Parkinson's Disease Treatment

This article delves into the role of monoamine oxidase B (MAO-B) inhibitors in the treatment of Parkinson's disease. Imagine Parkinson's disease as a vast desert landscape where the vital dopamine pathways are slowly eroding. MAO-B inhibitors are like skilled desert engineers, working to rebuild those pathways and restore functionality. This review explores the mechanisms of action of MAO-B inhibitors, highlighting their potential to alleviate symptoms and potentially even modify the course of the disease. The authors provide an update on the latest findings and discuss the potential benefits and limitations of these medications.

Restoring Balance: A Journey of Hope in Parkinson's Disease Treatment

This review presents a compelling case for the use of MAO-B inhibitors in the management of Parkinson's disease. It's like discovering a new oasis in the desert of Parkinson's research, offering a beacon of hope. The authors highlight the potential of these drugs to improve motor function, reduce tremors, and address non-motor symptoms. The review also emphasizes the importance of continued research to further explore the potential neuroprotective and disease-modifying effects of MAO-B inhibitors.

Navigating Parkinson's Disease: A Path Forward

This review underscores the importance of ongoing research in Parkinson's disease. It's like charting a new course through the ever-shifting sands of the disease landscape. The authors emphasize the need to identify new treatment strategies that can slow disease progression, improve quality of life, and ultimately lead to a cure. By investing in research, we can pave the way for a more hopeful future for individuals living with Parkinson's disease.

Dr. Camel's Conclusion

This review provides a valuable overview of the role of MAO-B inhibitors in Parkinson's disease treatment. It highlights the ongoing progress in our understanding of this complex disease and the promise of new therapeutic strategies. As researchers, we must continue to explore the vast desert of Parkinson's research, seeking new insights and breakthroughs that can improve the lives of patients and their families.

Date :
  1. Date Completed 2023-03-16
  2. Date Revised 2023-03-21
Further Info :

Pubmed ID

34970960

DOI: Digital Object Identifier

10.2174/1871527321666211231100255

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・Effects of safinamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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