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New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia.

Author: AlmeidaIgor C, Alonso-VegaCristina, DebrabantAlain, GarciaWilson, GasconJoaquim, GonzalezVirginia R, LozanoDaniel, LópezManuel Carlos, MaldonadoRosa A, MichaelKatja, NagarkattiRana, OrtizLourdes, PinazoMaría-Jesús, PintoJimy José, RibeiroIsabela, RojasGimena, SanzSergi, SchijmanAlejandro, SoyDolors, ThomasM Carmen, TorricoFaustino, UrbinaJulio A

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Chagas disease (CD) affects millions worldwide. While the main medications for CD (benznidazole and nifurtimox) work well in children and during the early stages, they are less effective in adults with chronic CD. These drugs also have significant side effects. Research suggests that giving these medications less often, but for a longer period, might be just as effective and cause fewer side effects.
Paper Details　
Original Abstract of the Article :
Chagas disease (CD) affects ~7 million people worldwide. Benznidazole (BZN) and nifurtimox (NFX) are the only approved drugs for CD chemotherapy. Although both drugs are highly effective in acute and paediatric infections, their efficacy in adults with chronic CD (CCD) is lower and variable. Moreove...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720984/

データ提供：米国国立医学図書館（NLM）

A New Oasis in the Desert of Chagas Disease: Exploring Novel Treatment Regimens

Chagas disease, a parasitic infection that affects millions of people worldwide, can be as challenging to treat as navigating a vast and treacherous desert. This study outlines the rationale and design of the TESEO clinical trial, a groundbreaking research endeavor exploring new chemotherapy regimens for Chagas disease.

A New Path Forward: Seeking More Effective and Tolerable Treatments

The TESEO study aims to evaluate the efficacy of lower-frequency dosing regimens of benznidazole (BZN) and nifurtimox (NFX) for chronic Chagas disease (CCD). The researchers hope to find a more effective and tolerable treatment approach, much like a group of explorers seeking a safer route through a challenging desert.

A Glimmer of Hope: The Potential for Improved Treatment

The TESEO study represents a beacon of hope for individuals struggling with Chagas disease. The researchers hope to develop more effective and better-tolerated treatment regimens, potentially improving the lives of millions affected by this devastating disease.

Dr. Camel’s Conclusion

This study explores a promising new approach to the treatment of Chagas disease. The TESEO trial represents a significant step forward in the quest to find more effective and tolerable therapies for this debilitating condition. Much like a desert explorer seeking a new oasis, researchers are working tirelessly to find better ways to combat this global health challenge.

Date :
  1. Date Completed 2022-03-07
  2. Date Revised 2022-03-07
Further Info :

Pubmed ID

34972765

DOI: Digital Object Identifier

PMC8720984

Related Literature

Article Analysis
・Effective treatment of chagas disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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