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Novel function of THEMIS2 in the enhancement of cancer stemness and chemoresistance by releasing PTP1B from MET.

Author: ChenPo-Ming, ChiHsiang-Cheng, ChuPei-Yi, HuangShih-Jei, HuangWei-Chieh, HuangYi-Ching, ShihYa-Chi, SungYu-Wen, TungShiao-Lin, WangLu-Hai, YenJia-Hau

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Triple negative breast cancer (TNBC) is a type of breast cancer with a poor prognosis. This study identified THEMIS2, a gene that plays a role in promoting cancer stemness in TNBC. The study also found that cryptotanshinone (CPT) can inhibit cancer stemness by suppressing THEMIS2 expression, suggesting a potential new therapeutic approach for TNBC.
Paper Details　
Original Abstract of the Article :
Triple negative breast cancer (TNBC) possesses poor prognosis mainly due to lack of effective endocrine or targeted therapies, aggressive nature and high rate of chemoresistance. Cancer stem cells (CSCs) are considered to play critical roles in cancer recurrence and chemoresistance. THEMIS2 was iden...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837547/

データ提供：米国国立医学図書館（NLM）

Triple-Negative Breast Cancer: Targeting Cancer Stem Cells

Triple-negative breast cancer (TNBC) is a particularly aggressive and challenging type of cancer. This research delves into the world of cancer stem cells (CSCs), a population of cells within tumors that contribute to cancer growth, recurrence, and resistance to treatment. The researchers focused on THEMIS2, a gene that is often elevated in TNBC and CSCs. They investigated the role of THEMIS2 in promoting CSC properties and resistance to chemotherapy. The study highlights THEMIS2 as a potential target for novel therapies aimed at inhibiting cancer stemness and improving treatment outcomes for TNBC patients.

THEMIS2: A Key Player in Cancer Stemness

The researchers found that THEMIS2 plays a key role in enhancing CSC properties, making tumors more aggressive and resistant to treatment. This finding provides a crucial insight into the complex mechanisms underlying TNBC and its resistance to therapy. It's like discovering a hidden oasis in the desert of cancer research, revealing a new target for therapeutic interventions.

A New Hope for TNBC Patients

This research offers a ray of hope for TNBC patients by identifying THEMIS2 as a potential therapeutic target. The study suggests that inhibiting THEMIS2 could effectively combat cancer stemness, potentially improving treatment outcomes for patients with this challenging disease. Just as a traveler in the desert searches for an oasis, so too do researchers tirelessly search for effective treatments for complex diseases like TNBC.

Dr.Camel's Conclusion

This research sheds light on the critical role of THEMIS2 in promoting cancer stemness and chemoresistance in TNBC. The findings open doors for the development of novel therapies targeting THEMIS2, providing a glimmer of hope for individuals battling this aggressive form of cancer. Just as a camel adapts to the harsh desert environment, so too must we adapt our strategies in the fight against cancer to overcome the challenges posed by this deadly disease.

Date :
  1. Date Completed 2022-02-23
  2. Date Revised 2022-10-26
Further Info :

Pubmed ID

34974522

DOI: Digital Object Identifier

PMC8837547

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Languages

English

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