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Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS.

Author: CarlssonBjörn, HelldénAnders, KarlssonLouise, ÄrlemalmAndreas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes a new method for simultaneously analyzing four antiviral drugs (acyclovir, 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir) in human serum using mass spectrometry. This method can be used for therapeutic drug monitoring and is accurate and reproducible.
Paper Details　
Original Abstract of the Article :
A novel MS-based analytical method for simultaneous analysis of the antiviral drugs acyclovir, its metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum is described. These antiviral drugs are active against herpes virus infections. Acyclovir and penciclovir are regar...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285573/

データ提供：米国国立医学図書館（NLM）

Rapid Determination of Acyclovir, Its Main Metabolite 9-Carboxymethoxymethylguanine, Ganciclovir, and Penciclovir in Human Serum Using LC-MS/MS

Viral infections are like desert plagues, capable of spreading rapidly and causing significant damage. This research focuses on developing a rapid and accurate method for analyzing the levels of antiviral drugs in human serum. The study describes a novel LC-MS/MS method for simultaneous analysis of acyclovir, its metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir.

LC-MS/MS: A Powerful Tool for Antiviral Drug Monitoring

The study developed a highly sensitive and reliable LC-MS/MS method for monitoring antiviral drugs in human serum. This is like having a sophisticated microscope to identify and track the movements of desert plagues, allowing for timely and effective interventions. The research provides a valuable tool for optimizing antiviral therapy and ensuring patient safety.

Antiviral Drug Monitoring: Ensuring Effective Treatment

This study highlights the importance of monitoring antiviral drug levels to optimize treatment efficacy and minimize potential side effects. It's a reminder that even in the unpredictable desert of viral infections, we have tools to combat these threats and protect human health.

Dr.Camel's Conclusion

This research provides a crucial tool for monitoring antiviral drug levels in patients. It's like having a vigilant lookout tower in the desert, constantly monitoring for signs of plague and ensuring that the right defenses are in place. By optimizing antiviral drug therapy, we can effectively combat viral infections and protect human health.
Date :
  1. Date Completed 2022-03-22
  2. Date Revised 2022-07-31
Further Info :

Pubmed ID

34981553

DOI: Digital Object Identifier

PMC9285573

SNS
PICO Info
in preparation
Languages

English

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