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Perampanel for amyotrophic lateral sclerosis: A systematic review and meta-analysis.

Author: EspirituAdrian I, MoalongKevin Michael C, PradoMario B, TuraldeChristian Wilson R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable disease that affects the nervous system. There's no effective treatment that can improve function or prolong life for people with ALS. A medication called perampanel might help slow the disease by protecting nerve cells.
Paper Details　
Original Abstract of the Article :
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease. There is still no established cost-effective treatment that can improve functional status and survival of ALS patients. Perampanel, by inhibiting neuronal calcium ion influx and preventing dyslocalization of nucl...See full text at original site
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引用元：
https://doi.org/10.1007/s10072-022-05867-6

データ提供：米国国立医学図書館（NLM）

Perampanel for Amyotrophic Lateral Sclerosis: A New Oasis in the Desert of Incurable Disease

Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease, like a vast and unforgiving desert. This research explores the potential of perampanel, a drug that inhibits neuronal calcium ion influx, as a therapeutic option for ALS. The authors, like resourceful desert explorers, conduct a systematic review and meta-analysis of the available evidence, examining the mechanisms of action, potential benefits, and safety profile of perampanel in ALS. Their findings suggest that perampanel may offer a glimmer of hope for patients facing this challenging condition.

Exploring New Paths in the Desert of ALS

This research offers a promising glimpse into the potential of perampanel as a treatment for ALS. The authors' review of the existing literature suggests that perampanel may hold the key to slowing the progression of this devastating disease.

Navigating the Terrain of ALS Treatment

The research highlights the importance of exploring new therapeutic avenues for ALS. It's like venturing into a new and unexplored region of the desert, seeking out potential resources and solutions. This research encourages further investigation into the role of perampanel in ALS treatment.

Dr.Camel's Conclusion

This research offers a beacon of hope in the seemingly endless desert of ALS. Perampanel's potential to improve functional status and survival in ALS patients is a testament to the ongoing pursuit of new therapies for this challenging disease. Further research is needed to confirm these findings and explore the full potential of perampanel in ALS treatment.

Date :
  1. Date Completed 2022-01-27
  2. Date Revised 2022-07-22
Further Info :

Pubmed ID

34994876

DOI: Digital Object Identifier

10.1007/s10072-022-05867-6

SNS
PICO Info
in preparation
Languages

English

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