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Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis.
Author: , CordtsIsabell, DorstJohannes, GrosskreutzJulian, GüntherKornelia, GüntherRené, HagenackerTim, HermannAndreas, KochBirgit, KochJan C, KohlZacharias, LingorPaul, LudolphAlbert C, LöscherWolfgang N, MaierAndré, MeyerThomas, MichelsSebastian, PetriSusanne, PrudloJohannes, RuckesChristian, SarikidiAnastasia, SpittelSusanne, SteinbachRobert, WitzelSimon, WolfJoachim
Original Abstract of the Article :
IMPORTANCE: Intravenous edaravone is approved as a disease-modifying drug for patients with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term beneficial effects shown in the MCI186-ALS19 study in a subpopulation in which efficacy was expected. OBJECTIVE: To eva...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749709/
データ提供:米国国立医学図書館(NLM)
Edaravone for ALS: A Journey Through the Desert of Neurological Disease
Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is like a relentless sandstorm in the desert of the nervous system. This study, a quest for effective treatments for ALS, explored the long-term safety and effectiveness of intravenous edaravone therapy in a real-world clinical setting.Edaravone: A Mirage in the Desert of ALS?
This study, a comprehensive investigation into the long-term effects of edaravone therapy, reveals that while intravenous edaravone therapy for patients with ALS was feasible and mainly well tolerated, it was not associated with any disease-modifying benefit. The results, like a mirage in the desert, suggest that edaravone may not provide a clinically relevant additional benefit compared to standard therapy alone. This finding underscores the urgent need for further research to develop more effective treatments for this devastating disease.Navigating the Desert of ALS: A Search for New Oases
The study highlights the challenges of treating ALS, a disease that continues to defy traditional therapies. While edaravone may not be the elusive oasis we hoped for, this research serves as a reminder that we must continue to explore the vast desert of ALS, seeking new solutions and innovative therapies to combat this devastating disease.Dr. Camel's Conclusion
This study underscores the urgent need for continued research to develop more effective treatments for ALS. The desert of ALS is vast and unforgiving, but with unwavering determination, we can continue to seek new oases of knowledge and innovation, offering hope to patients facing this challenging disease.Date :
- Date Completed 2022-03-08
- Date Revised 2023-01-11
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