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[A Case of Colon Cancer with Suspected DPD Deficiency Causing Severe Adverse Effects following Adjuvant Chemotherapy with Capecitabine].

Author: AokiHideki, ArakiHiroyuki, ArataTakashi, KatsudaKo, KimuraYuji, MinagiHitoshi, NagahisaSeiichi, OgawaToshihiro, TanakayaKoji, TaniguchiFumitaka, WatanabeMegumi

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A case report describes a 76-year-old female with colon cancer who experienced severe adverse effects from capecitabine chemotherapy, including mucositis, diarrhea, leukocytopenia, and DIC. These effects were suspected to be caused by a deficiency of DPD, an enzyme involved in the metabolism of capecitabine. This case highlights the importance of early diagnosis and management of DPD deficiency to prevent severe complications from chemotherapy.
Paper Details　
Original Abstract of the Article :
The present study reports a case of colon cancer in a 76-year-old female who underwent laparoscopic right colectomy. Pathological findings revealed pT3(SS), pN2a, cM0, and pStage Ⅲb. Hence, we administered adjuvant chemotherapy with capecitabine. On day 18, she was urgently hospitalized because of s...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35045450

データ提供：米国国立医学図書館（NLM）

A Case of Colon Cancer and DPD Deficiency: Navigating a Complex Medical Journey

Colon cancer is a formidable foe, and finding effective treatment strategies requires careful navigation through a complex medical landscape. This study presents a case of a 76-year-old woman who underwent surgery for colon cancer and subsequently experienced severe adverse effects during adjuvant chemotherapy with capecitabine. The researchers suspected a deficiency in dihydropyrimidine dehydrogenase (DPD), an enzyme crucial for metabolizing capecitabine, as the underlying cause of the complications.

DPD Deficiency: A Hidden Obstacle in Colon Cancer Treatment

This case study highlights the importance of recognizing and managing DPD deficiency, a potential complication of capecitabine therapy. The study emphasizes the need for careful patient selection and appropriate monitoring to prevent severe adverse effects and ensure optimal treatment outcomes.

Navigating the Terrain of Colon Cancer Treatment: A Cautionary Tale

This study serves as a reminder of the complexities of cancer treatment, especially in the context of genetic variations like DPD deficiency. The case highlights the need for a multidisciplinary approach, including genetic testing and individualized treatment plans, to ensure patient safety and optimal treatment outcomes.

Dr. Camel's Conclusion

Just as a camel adapts its journey through the desert to navigate treacherous terrain, we must be aware of potential roadblocks in cancer treatment. This case study underscores the importance of understanding individual patient characteristics and tailoring treatment strategies to ensure a safe and effective journey.

Date :
  1. Date Completed 2022-01-21
  2. Date Revised 2022-01-21
Further Info :

Pubmed ID

35045450

DOI: Digital Object Identifier

35045450

Related Literature

Article Analysis
・Effects of capecitabine
SNS
PICO Info
in preparation
Languages

Japanese

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