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The effect of intervention versus watchful waiting on disease progression and overall survival in smoldering multiple myeloma: a systematic review of randomized controlled trials.

Author: AkinyemiOluwasegun, AliAhmed, AraoyeMojisola O, AsemotaJoseph, OjoAdemola S, OjukwuSomtochukwu G, SalehMohammed, SarmaRavi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review summarized the current evidence regarding the management of smoldering multiple myeloma (SMM), considering the lack of consensus on the optimal treatment approach.
Paper Details　
Original Abstract of the Article :
Smoldering multiple myeloma (SMM) is an intermediate pre-malignant condition with individuals having a distinct risk of progression to overt myeloma. The optimal management option has remained controversial due to the heterogeneous nature of the condition in which progression to overt diseases is va...See full text at original site
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引用元：
https://doi.org/10.1007/s00432-022-03920-7

データ提供：米国国立医学図書館（NLM）

Intervention vs. Watchful Waiting for Smoldering Multiple Myeloma

Imagine a desert with shifting sands, where the landscape is constantly changing. This is analogous to smoldering multiple myeloma (SMM), a pre-cancerous condition where the risk of progression to overt myeloma is uncertain. This research examines the effectiveness of intervention versus watchful waiting in managing SMM. The study systematically reviews randomized controlled trials to assess the impact of treatment on disease progression and overall survival.

Managing Smoldering Multiple Myeloma: Balancing Intervention and Observation

This study highlights the complexity of managing SMM, where the optimal approach remains controversial. The findings underscore the need for individualized decision-making based on patient factors, such as risk of progression and potential benefits and risks of treatment. This research provides a valuable framework for clinicians to navigate this challenging clinical scenario.

Understanding Multiple Myeloma: Early Detection and Treatment

Multiple myeloma is a serious blood cancer. Early detection and prompt treatment are essential for improving outcomes. If you experience any symptoms of multiple myeloma, it's crucial to consult with a healthcare provider for a thorough evaluation. Don't hesitate to seek medical attention if you have concerns about your health.

Dr. Camel's Conclusion

This research delves into the complex world of smoldering multiple myeloma, exploring the pros and cons of intervention versus watchful waiting. The study emphasizes the need for individualized decision-making based on patient factors and the importance of ongoing research to improve our understanding and management of this challenging condition. With continued research and a personalized approach, we can work towards improving outcomes for patients with smoldering multiple myeloma.
Date :
  1. Date Completed 2022-03-21
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

35059867

DOI: Digital Object Identifier

10.1007/s00432-022-03920-7

Related Literature

Article Analysis
・Effective treatment of multiple myeloma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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