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Natural compound library screening identifies Sanguinarine chloride for the treatment of SCLC by upregulating CDKN1A.
Author: ChenKaizhao, HuangYanni, LiXun, LiuMing, LongYihao, MaXiaodong, TianXuemei, ZhaoFengyun, ZhongMingtian
Original Abstract of the Article :
OBJECTIVES: Small cell lung cancer (SCLC) is notorious for aggressive malignancy without effective treatment, and most patients eventually develop tumor progression with a poor prognosis. There is an urgent need for discovering novel antitumor agents or therapeutic strategies for SCLC. MATERIALS AN...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789530/
データ提供:米国国立医学図書館(NLM)
A Novel Natural Compound for Treating Small Cell Lung Cancer: Sanguinarine Chloride
Small cell lung cancer (SCLC) is a highly aggressive and challenging cancer to treat. This research investigates the potential of a natural compound, sanguinarine chloride, as a novel therapeutic agent for SCLC. The study explores the compound's effects on SCLC cells, identifying its mechanism of action and investigating its potential synergistic effects with other anti-cancer drugs.
Sanguinarine Chloride Shows Promise in Targeting SCLC
The study revealed that sanguinarine chloride effectively inhibited SCLC cell proliferation, colony formation, migration, and invasion, and induced apoptosis. The research identified CDKN1A, a gene involved in cell cycle regulation, as a key target of sanguinarine chloride's anti-cancer activity. The study further demonstrated the potential for synergistic effects when sanguinarine chloride is combined with other anti-cancer drugs, highlighting its potential as a promising therapeutic agent for SCLC.
A New Hope for Treating Small Cell Lung Cancer
This research provides exciting insights into the potential of sanguinarine chloride as a novel therapeutic agent for SCLC. The study's findings suggest that this natural compound could significantly impact the treatment of this aggressive cancer, offering new hope for patients.
Dr. Camel's Conclusion
The search for effective treatments for small cell lung cancer is like searching for a hidden oasis in a vast and unforgiving desert. This research has uncovered a potential treasure in the form of sanguinarine chloride, a natural compound with promising anti-cancer properties. The findings offer a beacon of hope for patients with SCLC, suggesting a new path towards effective treatment and improved outcomes.
Date :
- Date Completed n.d.
- Date Revised 2023-10-19
Further Info :
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