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Assessment of bone marrow-derived mesenchymal stem cells capacity for odontogenic differentiation and dentin regeneration in methimazole-treated albino rats (Light microscopic Study).

Author: RabeaAmany A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methimazole, an antithyroid drug, can damage tissues. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been shown to improve tissue regeneration. This study investigated the effect of BM-MSCs on dentin regeneration in methimazole-treated rats. Results showed that BM-MSCs increased odontogenic differentiation and dentin regeneration in a time-dependent manner. Methimazole caused damage to dentin, but BM-MSCs helped to restore its structure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Methimazole is an antithyroid drug. It has side effects on many tissues. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are promising in the field of tissue regeneration. OBJECTIVE: To investigate the capacity of BM-MSCs on odontogenic differentiation and dentin regeneration at di...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767165/

データ提供：米国国立医学図書館（NLM）

Methimazole and Dentin Regeneration: A Desert Oasis of Stem Cell Research

Methimazole, a medication used to treat hyperthyroidism, can have unintended consequences, including potential damage to bone tissue. This research investigates the capacity of bone marrow-derived mesenchymal stem cells (BM-MSCs) to differentiate into odontoblasts and promote dentin regeneration in methimazole-treated rats.

BM-MSCs: A Desert Oasis of Healing

The study found that BM-MSCs demonstrated a time-based increase in their capacity for odontogenic differentiation and dentin regeneration. This suggests that BM-MSCs may offer a promising approach for restoring damaged dentin, particularly in cases where methimazole treatment has led to adverse effects.

Methimazole and Dentin Regeneration: A Desert Oasis of Hope

This research provides encouraging evidence for the potential of BM-MSCs in promoting dentin regeneration. It highlights the importance of exploring stem cell therapies for addressing bone tissue damage, particularly in cases where traditional treatment options have limited success.

Dr. Camel's Conclusion

This study offers valuable insights into the regenerative potential of BM-MSCs in addressing dentin damage caused by methimazole treatment. It underscores the importance of continued research into stem cell-based therapies for bone regeneration, offering hope for individuals experiencing bone tissue damage due to medications or other factors.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

35068896

DOI: Digital Object Identifier

PMC8767165

Related Literature

Article Analysis
・Side Effects of methimazole
SNS
PICO Info
in preparation
Languages

English

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