Paper Details 
Original Abstract of the Article :
Imatinib, nilotinib, dasatinib, bosutinib, ponatinib, and asciminib are FDA-approved tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML), each of which has a specific pharmacological profile. Asciminib has been recently (2021) approved for patients resistant to former TKIs, and beca...See full text at original site
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引用元:
https://doi.org/10.1007/s11010-022-04376-6

データ提供:米国国立医学図書館(NLM)

A Journey Through the Desert of Chronic Myeloid Leukemia Treatment

The [desert of chronic myeloid leukemia (CML)] is a harsh and unforgiving landscape, but research continues to uncover new ways to combat this disease. This review examines the [transport and metabolism of tyrosine kinase inhibitors (TKIs)], a class of drugs used to treat CML. The authors delve into the unique pharmacological profiles of various TKIs, including their absorption, distribution, metabolism, and excretion. This comprehensive review aims to provide a better understanding of how these medications work within the body, ultimately guiding clinicians towards more personalized treatment approaches.

A Comprehensive Guide to Navigating the Desert of TKIs

This review, like a detailed map of the desert, provides a comprehensive overview of the pharmacokinetics of TKIs used to treat CML. The information presented helps clinicians to make more informed decisions about the selection of TKIs for individual patients, considering factors such as drug-specific characteristics, potential drug interactions, and individual patient needs. Imagine a desert traveler with a reliable map, able to navigate the treacherous terrain with confidence and make informed choices about their journey. This review empowers clinicians to do the same for their patients, helping them navigate the complex landscape of CML treatment.

Living with CML: Finding the Oasis of Hope

While TKIs have revolutionized the treatment of CML, managing this disease remains a challenging journey. Understanding the intricacies of TKI pharmacokinetics, as described in this review, is crucial for optimizing treatment outcomes and minimizing side effects. Just as a desert traveler seeks out oases to replenish their resources, individuals with CML need to work closely with their healthcare providers to manage their disease and maintain a good quality of life. By navigating the desert of CML with knowledge, support, and determination, we can find the oasis of hope and live fulfilling lives.

Dr.Camel's Conclusion

This review, like a compass guiding us through the vast desert of CML treatment, provides invaluable insights into the pharmacokinetics of TKIs. By understanding how these medications work within the body, we can make more informed decisions about treatment, potentially leading to better outcomes and reduced side effects. The journey through CML can be challenging, but with knowledge, research, and a strong support network, we can navigate the desert and find the oasis of hope.

Date :
  1. Date Completed 2022-03-24
  2. Date Revised 2023-06-28
Further Info :

Pubmed ID

35129779

DOI: Digital Object Identifier

10.1007/s11010-022-04376-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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