IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Author: Bloms-FunkePetra, BoeslIrmgard, CaspaniOmbretta, ChapmanSonya C, FardoFrancesca, FinnerupNanna B, GenserBernd, GoetzMarcus, KostenkoAnna V, LeoneCaterina, LiThomas, MourauxAndré, NochiZahra, PelzBernhard, PhillipsKeith G, PiaHossein, Pogatzki-ZahnEsther, SchilderAndreas, SchnetterErik, SchubartKarin, StouffsAlexandre, TankisiHatice, TraceyIrene, TreedeRolf-Detlef, TroconizIñaki F, TruiniAndrea, Van NielJohannes, VelaJose Miguel, VincentKaty, VollertJan, WanigasekeraVishvarani, WittayerMatthias

Overview

This study focuses on biomarkers derived from nerve excitability testing (NET) to accelerate the development of analgesics for chronic pain.

Paper Details　

Original Abstract of the Article :

Few new drugs have been developed for chronic pain. Drug development is challenged by uncertainty about whether the drug engages the human target sufficiently to have a meaningful pharmacodynamic effect. IMI2-PainCare-BioPain-RCT1 is one of four similarly designed studies that aim to link different ...See full text at original site

Dr.Camel's Paper Summary Blog

Investigating the Effects of Analgesics on Pain Processing

This study protocol outlines a randomized, double-blind, placebo-controlled, crossover, multi-center trial designed to investigate the effects of three different analgesics on biomarkers of pain processing. The study will use peripheral nerve excitability testing (NET) to measure the pharmacodynamic effects of lacosamide, pregabalin, and tapentadol on the nociceptive system. This research aims to develop a better understanding of the mechanisms by which these drugs exert their analgesic effects.

Advancing the Development of New Analgesics

The study aims to link different functional biomarkers of drug effects on the nociceptive system, potentially accelerating the development of new analgesics. By identifying specific biomarkers that correlate with analgesic effects, researchers can better understand the mechanisms of action of different drugs and develop more effective and targeted treatments for chronic pain.

Improving Pain Management and Alleviating Suffering

This research represents a significant step towards improving pain management and alleviating suffering for individuals living with chronic pain. By developing a better understanding of the mechanisms by which analgesics work, researchers can develop more effective and targeted treatments, potentially offering hope for a better quality of life for millions of people worldwide.

Dr.Camel's Conclusion

This research, like a beacon of hope in the vast desert of pain, is dedicated to understanding the complexities of pain processing and developing better treatments for chronic pain. By investigating the effects of analgesics on specific biomarkers, researchers are paving the way for more targeted and effective pain management strategies. This research is a testament to the unwavering pursuit of knowledge and the desire to improve the lives of those suffering from chronic pain.