Consolidation and maintenance therapy in multiple myeloma: randomized comparison of a new approach to therapy after initial response to treatment.

Author: BartolucciA A, CohenH J, FormanW B, SilbermanH R

Paper Details 
Original Abstract of the Article :
A randomized, controlled trial was initiated in 1977 to evaluate the impact of three alternative approaches to consolidation and maintenance therapy after initial maximal response for multiple myeloma. All patients were treated initially with BCNU, cyclophosphamide, and prednisone (BCP) until a desi...See full text at original site
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引用元:
https://doi.org/10.1200/JCO.1986.4.6.888

データ提供:米国国立医学図書館(NLM)

Tailoring Treatment for Multiple Myeloma: A Randomized Comparison of Consolidation Therapies

The realm of [multiple myeloma treatment] is an ever-evolving desert, where researchers constantly seek the most effective oases for patients. This study, like a seasoned caravan leader, navigated the complexities of [consolidation therapy] after initial response to treatment. Their [randomized controlled trial] aimed to compare three different approaches: melphalan and prednisone (MP), prednisone, Adriamycin, azathioprine, and vincristine (PAIV), and no therapy until relapse followed by BCP. They found that, much like how a camel adapts to the desert, patients responded similarly to all three approaches, indicating that additional therapy may offer little advantage once an initial response is achieved. This finding, like a well-worn path, suggests that a simpler, more tailored approach might be better suited for this challenging condition.

Survival Rates Remain Steady

This study unearthed a fascinating detail: despite the different consolidation strategies, survival rates remained the same across all groups. This finding, like a stable oasis, suggests that while additional therapy might offer some benefits, it doesn't significantly affect the long-term outcome for patients.

Navigating the Desert of Multiple Myeloma Treatment

This research underscores the importance of individualized patient care and the need for a personalized approach in [multiple myeloma treatment]. Just as a traveler would choose their route based on their resources and needs, healthcare providers should carefully select the most appropriate treatment strategy for each patient, considering factors like individual response, tolerance, and overall health. This study, like a roadmap, provides valuable insights for navigating the challenging terrain of [multiple myeloma treatment], helping to guide patients towards the best possible outcome.

Dr.Camel's Conclusion

This research sheds light on the effectiveness of different consolidation therapies for multiple myeloma. While it's exciting to explore new avenues for treatment, it's equally important to remember that the best approach is often the simplest. Just as a camel adapts to the desert by conserving its energy, we should focus on providing the most effective therapy while minimizing unnecessary interventions.

Date :
  1. Date Completed 1986-07-22
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

3519879

DOI: Digital Object Identifier

10.1200/JCO.1986.4.6.888

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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