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Antihypertensive therapy with triamterene-hydrochlorothiazide vs amiloride-hydrochlorothiazide. Comparison of effects on urinary prostaglandin E2 excretion.

Author: ZawadaE T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amiloride hydrochloride-hydrochlorothiazide (Moduretic) increased renal PGE2 production, while triamterene-hydrochlorothiazide (Dyazide) decreased renal PGE2 production. This difference is an important renal consequence of using either drug.
Paper Details　
Original Abstract of the Article :
Amiloride hydrochloride has now been recognized as a safe and effective potassium-sparing diuretic alternative to triamterene with a similar mechanism of pharmacologic activity. Studies were undertaken to assess the difference between therapy with the triamterene-hydrochlorothiazide combination (Dya...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3521523

データ提供：米国国立医学図書館（NLM）

Diuretic Therapy: A Prostaglandin Perspective

Diuretic therapy, a mainstay in the management of hypertension, can have diverse effects on the body. This study compares the effects of [triamterene-hydrochlorothiazide] and [amiloride-hydrochlorothiazide] combinations on [urinary prostaglandin E2 excretion], a marker of renal function. The study found that [amiloride-hydrochlorothiazide] therapy increased [urinary prostaglandin E2 excretion] while [triamterene-hydrochlorothiazide] therapy decreased it. These findings highlight the importance of considering the impact of diuretic therapy on renal prostaglandin production when choosing between these drug combinations.

Diuretic Therapy: A Prostaglandin-Based Approach

This study provides valuable insights into the effects of different diuretic combinations on renal prostaglandin production. The findings suggest that the choice of diuretic therapy may have implications for renal function and should be carefully considered based on the patient's individual needs and potential risks.

Understanding Diuretic Therapy

If you are undergoing diuretic therapy for hypertension, understanding the potential effects on your body is essential. This study highlights the different ways in which diuretic combinations can impact renal prostaglandin production, providing valuable information for you and your doctor to consider during treatment decisions.

Dr.Camel's Conclusion

The choice of diuretic therapy can be like navigating a desert with multiple paths. This study helps illuminate the different effects of various diuretic combinations on renal prostaglandin production, guiding us towards a more informed and personalized approach to hypertension management.

Date :
  1. Date Completed 1986-07-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3521523

DOI: Digital Object Identifier

3521523

SNS
PICO Info
in preparation
Languages

English

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