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Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats.

Author: AlotaibiN M, MuradH A, Shaikh-OmarA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Roflumilast, a highly selective oral phosphodiesterase IV inhibitor, partially improved TNBS-induced chronic colitis in rats, suggesting the potential of roflumilast as an additional treatment for Crohn's disease. Both oral and rectal roflumilast improved disease activity scores, serum TNF-α, IL-2, and IL-6 levels, and colonic myeloperoxidase and malonaldehyde content.
Paper Details　
Original Abstract of the Article :
Roflumilast, a highly selective oral phosphodiesterase IV inhibitor, exerts anti-inflammatory and anti-fibrotic effects. Oral roflumilast causes gastrointestinal side effects, especially vomiting, which could be reduced by administering roflumilast via off-label routes. Inhaled roflumilast reportedl...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905672/

データ提供：米国国立医学図書館（NLM）

Roflumilast: A New Oasis in the Desert of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), a chronic condition affecting the digestive system, is like a relentless desert storm, causing inflammation and discomfort. This study explores the potential of roflumilast, a selective phosphodiesterase IV inhibitor, in alleviating the symptoms of IBD. The researchers used a rat model of colitis, a common approach for studying IBD, to investigate the effects of roflumilast administered orally and rectally, providing insights into its therapeutic potential.

Roflumilast: A Promising Approach for Treating Inflammatory Bowel Disease

The study reveals that both oral and rectal roflumilast demonstrated significant improvements in colitis activity scores, inflammatory markers, and histological changes in rats with TNBS-induced colitis. This suggests that roflumilast holds promise as an additional treatment for IBD, offering hope to patients seeking relief from their debilitating symptoms. The study also highlights the potential benefits of rectal administration of roflumilast, which could minimize gastrointestinal side effects.

Navigating the Desert of Inflammatory Bowel Disease: Seeking Effective Treatments

This study provides a valuable contribution to the search for effective treatments for IBD. Roflumilast, with its anti-inflammatory and anti-fibrotic properties, emerges as a potential new oasis in the desert of IBD. Further research is crucial to fully understand its efficacy and safety in human patients, paving the way for more targeted and effective treatments.

Dr. Camel's Conclusion

The findings of this study offer a glimmer of hope in the desert of IBD. Roflumilast, with its ability to alleviate symptoms and improve histological changes, holds promise as an additional treatment option. This research provides a valuable stepping stone towards developing more effective and targeted therapies for those battling this debilitating disease.

Date :
  1. Date Completed 2022-03-07
  2. Date Revised 2022-03-19
Further Info :

Pubmed ID

35239781

DOI: Digital Object Identifier

PMC8905672

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Article Analysis
・Side Effects of roflumilast
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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