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Treatment of early-stage mycosis fungoides with oral bexarotene and phototherapy: A systematic review and meta-analysis.

Author: GinsburgErica, HennessyKerry, MhaskarRahul, Seminario-VidalLucia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Combination therapy with oral bexarotene and phototherapy is a therapeutic option for early-stage MF. A systematic review and meta-analysis of 17 studies indicated that the overall response rate was 64.48%. Common side effects of bexarotene included hypertriglyceridemia, hypothyroidism, and hypercholesterolemia.
Paper Details　
Original Abstract of the Article :
Mycosis fungoides (MF) is a rare subtype of non-Hodgkin lymphoma, for which no standard treatment exists. The objective of this study is to provide evidence-based recommendations for adult patients with early-stage MF treated with oral bexarotene and phototherapy. A systematic review and meta-analys...See full text at original site
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引用元：
https://doi.org/10.1111/dth.15418

データ提供：米国国立医学図書館（NLM）

A New Oasis in the Desert of Mycosis Fungoides: Treatment with Oral Bexarotene and Phototherapy

This systematic review and meta-analysis explores the effectiveness of oral bexarotene and phototherapy as a combined treatment for early-stage mycosis fungoides (MF), a rare form of non-Hodgkin lymphoma. It synthesizes existing evidence to evaluate the efficacy and safety of this treatment approach.

Navigating the Shifting Sands of Treatment Options: A Comprehensive Overview

The review suggests that combination therapy with oral bexarotene and phototherapy shows promising results in treating early-stage MF, with a significant proportion of patients achieving partial or complete responses. The analysis also highlights the potential for side effects associated with bexarotene, including hypertriglyceridemia, hypothyroidism, and hypercholesterolemia.

A Journey Through the Oasis of Effective Treatment: A Guide for Patients and Clinicians

The review provides valuable information for patients and clinicians considering this treatment approach for early-stage MF. It highlights the potential benefits and risks of combination therapy, emphasizing the need for careful monitoring and individualized care to ensure optimal outcomes and manage potential side effects.

Dr.Camel's Conclusion

This systematic review and meta-analysis offers a comprehensive perspective on the use of oral bexarotene and phototherapy for early-stage MF. The findings suggest that this combination therapy holds potential for effective treatment, but further research is needed to establish clear guidelines and optimize treatment strategies, ensuring a smoother journey through the desert of MF treatment and maximizing the benefits for patients.

Date :
  1. Date Completed 2022-05-06
  2. Date Revised 2022-07-12
Further Info :

Pubmed ID

35243730

DOI: Digital Object Identifier

10.1111/dth.15418

Related Literature

Article Analysis
・Side Effects of bexarotene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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